Man Utd make the short trip across the city to face Man City in the second instalment of the Manchester Derby in the Premier League this term.
Pep Guardiola's side currently sit six points clear of Liverpool at the top of the table - having played a game more - but they have lost each of their last three clashes with Man Utd at the Etihad Stadium.
United, meanwhile, have top four ambitions and they will be looking to right the wrongs from November's disappointing 2-0 defeat to their bitter rivals at Old Trafford.
Here's everything you need to know about the game.
How to watch Man City vs Man Utd on TV/live stream
When is kick off? Sunday 6 March, 16:30 (GMT)
Where is it being played? Etihad Stadium
What TV channel is it on? Sky Sports Main Event (UK), fuboTV (US)
Highlights? Sky Sports Football YouTube, BBC Match of the Day 2 (22:30)
Referee? Michael Oliver
VAR? Stuart Attwell
Man City team news
Pep Guardiola was afforded the luxury of rotating the likes of Rodri, Raheem Sterling and Kevin De Bruyne for his side's midweek FA Cup win over Peterborough.
However, the Cityzens will be without Ruben Dias for four to six weeks after the Portuguese was withdrawn in that one with a hamstring injury. Cole Palmer will not feature either.
Man Utd team news
Scott McTominay should be back for Man Utd after the Scotland international missed last weekend's goalless draw with Watford through illness.
Ralf Rangnick also believes Edinson Cavani has a good chance of returning. The Uruguayan has been missing with a groin problem for the last five games.
Man City vs Man Utd head-to-head record
United will be keen to lay a glove on their city rivals this time around after an alarmingly one-sided Manchester Derby defeat in the reverse fixture at Old Trafford in November.
Indeed, previous Man Utd boss Ole Gunnar Solskjaer boasted a strong record against Pep Guardiola's side, famously doing the double over City in the 2019/20 Premier League campaign.
United have won on each of their last three visits to the Etihad Stadium, with the fixture dynamic tending to favour the Red Devils' counter-attacking approach.
Man City vs Man Utd score prediction
Those of a Liverpool persuasion will be hoping for a favour from their bitter rivals as the gap narrows at the top of the Premier League.
Complacency has undermined Man City in this fixture at the Etihad Stadium in recent years, although there should be little worry that Guardiola's side take their eye off the ball this weekend.
Having rested several key hitters for the FA Cup win over Peterborough, City will enter this derby fresh and with a point to prove.
Prediction: Man City 2-0 Man Utd