Ralf Rangnick will take charge of his first game as Manchester United manager as he welcomes Crystal Palace to Old Trafford.
The German had a watching brief in midweek as United secured a 3-2 victory over Arsenal, before stating at his unveiling on Friday that he is keen to tighten up the side's defence.
Palace will arrive in Manchester on the back of successive league defeats, the most recent of which coming via an injury time winner from Leeds in midweek.
Here's everything you need to know about the game.
How to watch Man Utd vs Crystal Palace on TV/live stream
When is kick off? Sunday 5 December, 14:00 (GMT)
Where is the match being played? Old Trafford
TV channel/live stream? BBC Radio Manchester (UK), NBCSN/fuboTV (US)
Highlights? Sky Sports YouTube, Match of the Day 2 (UK)
Referee? Craig Pawson
VAR? Simon Hooper
Man Utd team news
For his first United lineup, Rangnick will be without Paul Pogba and Raphael Varane, while there are major doubts over the involvement of both Luke Shaw and Edinson Cavani.
Aaron Wan-Bissaka missed out against Arsenal with a hand injury but should be back in contention for this one.
You can read Man Utd's predicted lineup here.
Crystal Palace team news
Joachim Andersen's absence was keenly felt by Vieira in his side's 1-0 defeat to Leeds in midweek, but he could be back for this one after responding well to treatment on his hamstring injury.
Meanwhile, James McArthur will miss the next month with a hamstring injury and Nathan Ferguson is a long-term absentee. Right-back Joel Ward is suspended.
You can read Crystal Palace's predicted lineup here.
Man Utd vs Crystal Palace head-to-head record
United have won just one of their previous four meetings against Crystal Palace stretching back to last season.
In fact, the Eagles are unbeaten in their last three visits to Old Trafford, claiming victory in two of them. Last season's clash between the sides in Manchester went the way of Palace with a brace from Wilfried Zaha, once of a United persuasion, in a 3-1 win.
Man Utd vs Crystal Palace score prediction
The new manager bounce is a fascinating phenomenon and United will hope to benefit at the start of a run of fixtures which looks especially kind.
Crystal Palace have been derailed in recent weeks with back-to-back defeats, and the counter-attacking style which has hurt United in previous meetings has been abandoned for a more ball-dominant system.
Expect the individual quality of United to take over in the end.
Prediction: Man Utd 2-0 Crystal Palace