Tottenham's preparations for Sunday's Premier League clash with Newcastle have been disrupted by two positive Covid-19 tests.
There has been no official statement from the club about which two players have tested positive, but various sources have confirmed the news - hours after Nuno Espirito Santo said in his press conference that he'd been left with "huge issues" following the latest international break.
Sky Sports News note that both players trained with Tottenham's first team on Thursday and were shown to have contracted Covid-19 after tests in the last 24 hours.
Protocol now states that the affected players - who have not been named but are speculated to be Son Heung-min and Bryan Gil - must isolate for ten days, ruling the pair out of not only the weekend clash against Newcastle, but also the Europa Conference League tie with Vitesse Arnhem and the Premier League game against West Ham.
Nuno already had a selection headache for the trip to St James' Park, with four established members of his squad unlikely to feature because of travelling back from international duty in South America.
Giovani Lo Celso and Cristian Romero have been away representing Argentina, while Davinson Sanchez has been playing for Colombia. Emerson Royal, meanwhile, has been part of Brazil's squad for their recent World Cup qualifiers.
Speaking about whether or not the quartet would play, Nuno simply said in his pre-match press conference: "They are travelling now. They will join us tomorrow and then we'll see."
The former Wolves boss also provided an update on winger Steven Bergwijn, who has not played for the club since picking up an injury in the 1-0 win over Watford at the back end of August.
"He [Bergwijn] joined us yesterday. He is totally integrated in the group. He did well. No pain and now about getting back to his highest levels of fitness," Nuno revealed. "After the international break there are always problems. We have problems but I won't say them before the game."
To make matters worse, Spurs are likely to come against a buoyant Newcastle side not only looking to win their first game of the season, but also one determined to prove their worth to their new mega-rich owners.