Spurs come into the game having lost their last two Premier League matches and winless in three - a run that has seen them slip from the summit to sixth place in the table. They did, however, rediscover their winning touch in midweek as they triumphed over Stoke in the EFL Cup quarter-finals.
Wolves, meanwhile, have won just once in four games throughout December, losing the other three. They were defeated 2-1 at Burnley on Monday having previously stolen a win in thrilling fashion against Chelsea the week before. Nuno will likely go with his strongest side against Spurs in an attempt to get back to winning ways.
Here's the lineup that should start to do just that.
1. Goalkeeper & Defenders
Rui Patricio (GK) - Wolves' number one has kept four clean sheets so far this campaign and will look to make it five on Sunday evening.
Willy Boly (CB) - The defender did not feature on Monday and will likely come back into the side to replace Max Kilman.
Conor Coady (CB) - The Wolves captain has featured in all but one of their Premier League games thus far, and provides excellent passing ability from the back, as well as his defensive prowess.
Roman Saiss (CB) - The Moroccan is the preferred option to play alongside Boly and Coady at the back and Nuno will likely stick with him on the left of the three central defenders.
2. Wing-Backs & Midfielders
Nelson Semedo (RWB) - The former Barcelona man has impressed since joining the club, ranking first for dribbles completed (26) among Premier League defenders. He's sure to start on the right.
Ruben Neves (CM) - Essential in their creative play, racking up a whopping 73 passes into the final third so far this season - 40 more than any other Wolves player. Guaranteed starter.
Joao Moutinho (CM) - Another Portugal international, and another crucial cog in the Wolves system. Usually a real creative presence, but he will be looking to get his first assist of the season against Spurs.
Rayan Ait-Nouri (LWB) - In Jonny's absence, the France Under-21 international has done well, making 11 tackles and interceptions in just five appearances this season.
Daniel Podence (CF) - The forward has performed outstandingly when given a free role behind the strikers. He seems to glide around players and pick up pockets of space with ease. A real threat on his day.
Pedro Neto (ST) - The forward has the second highest goals per 90 minutes ratio at the club, only beaten by Raul Jiminez. He provides a danger in the final third, and can hurt teams with his pace.
Fabio Silva (ST) - In Jiminez's absence, Silva has found it difficult to become the talisman for his side, but the 18-year old has performed well and shown promise. He'll look to build on scoring his first goal at Turf Moor on Monday, when he became Wolves' youngest ever Premier League goal scorer.