Sevilla will look to pile on the misery when they take on Real Madrid in La Liga on Saturday afternoon at the Ramon Sanchez-Pizjuan.
Both sides were well beaten in midweek in the Champions League but in wildly different circumstances, with Sevilla already qualified and Real Madrid fighting for their lives in the competition.
In La Liga they sit in fourth and fifth place respectively, but Sevilla have played a game fewer and Madrid manager Zinedine Zidane knows his future is in the spotlight following recent results.
Where to Watch
When Is Kick Off? Saturday 5 December
What Time Is Kick Off? 15:15 (GMT)
Where Is it Played? Ramon Sanchez-Pizjuan Stadium
TV Channel/Live Stream? La Liga TV (UK)
Sevilla were battered at home to Chelsea in midweek, but manager Julen Lopetegui was able to almost fully rotate his team in preparation for this clash.
Marcos Acuna and Suso are doubtful with injuries, while Sergio Escudero is definitely out of the game after fracturing his elbow.
Real Madrid have their own fitness concerns with Dani Carvajal, Eden Hazard and Fede Valverde all ruled out of the game with injury. Sergio Ramos has missed the last four games with a muscle injury but could return against his former club if Zidane decides to risk him. Eder Militao has recovered from Covid-19 and could deputise at centre-back.
Sevilla: Vaclik; Navas, Kounde, Carlos, Rekik; Rakitic, Fernando, Jordan; Ocampos, De Jong, Torres
Real Madrid: Courtois; Nacho, Varane, Militao, Mendy; Casemiro, Kroos, Odegaard; Asensio, Benzema, Vinicius Jr
Sevilla had been in great form, with the defeat to Chelsea snapping a five-game winning streak. They currently sit in fifth place in La Liga eight points off the top of the league, having played two games fewer than league leaders Real Sociedad.
Real Madrid, on the other hand, have won just once in the last five games, conceding nine goals in the process. They have looked lethargic and slow in their recent games but with Zidane's job on the line, the players will be keen to step up and show they are still the same group that won the league last season.
Sevilla 1-0 Osasuna (7/11)
Sevilla 4-2 Celta Vigo (21/11)
Krasnodar 1-2 Sevilla (24/11)
Huesca 0-1 Sevilla (28/11)
Sevilla 0-4 Chelsea (2/12)
Valencia 4-1 Real Madrid (8/11)
Villarreal 1-1 Real Madrid (21/11)
Inter Milan 0-2 Real Madrid (24/11)
Real Madrid 1-2 Alaves (28/11)
Shakhtar 2-0 Real Madrid (1/12)
A very interesting clash between two sides who will want to be in and around the top of the table come the end of the season. Lopetegui will want to get revenge on his former side, but Madrid have won their last three games against Sevilla including their last visit to Andalusia.
The home side will come into the game with all their starters fresh and ready to play, while Madrid will be loaded with pressure knowing that they must win to keep Zidane in a job.
The Frenchman will be very aware of reports that his job hangs on qualification from the Champions League, meaning he needs a result in Wednesday's fixture against Gladbach. That could mean he rests some players for that game and with one eye on the fixture, and Sevilla should be able to take advantage.
With their exciting style of football and attacking players in good form, they will be confident they can get the result here. Luuk de Jong will be a constant threat from set pieces and with Madrid shaky defensively, they will concede and subsequently open up even more.
Prediction: Sevilla 2-1 Real Madrid