Real Madrid will continue the defence of their Champions League crown with a visit from Bundesliga side RB Leipzig.
An emphatic 3-0 victory away at Celtic was a perfect start to the competition for Carlo Ancelotti's men, who are one of the few sides across Europe who still boast a 100% record in all competitions.
They're up against a wounded Leipzig side who recently made a change in the dugout as Domenico Tedesco was replaced by Marco Rose - a decision that yielded immediate reward in the form of a 3-0 thumping of Borussia Dortmund at the weekend.
Here's all you need to know about this one.
Where are Real Madrid vs RB Leipzig playing?
- Location: Madrid, Spain
- Stadium: Santiago Bernabeu
- Date: Wednesday 14 September
- Kick-off Time: 20:00 BST / 15:00 EST / 12:00 PST
- VAR: Massimiliano Irrati (ITA)
- Referee: Maurizio Mariani (ITA)
Where can you watch Real Madrid vs RB Leipzig on TV in UK, US, Canada?
- UK: BT Sport 4
- USA: Paramount+
- Canada: DAZN
Where can you watch Real Madrid vs RB Leipzig highlights in UK, US, Canada?
- UK: BT Sport YouTube channel
- USA: CBS Sports Golazo YouTube channel
- Canada: DAZN Canada YouTube channel
Real Madrid vs RB Leipzig H2H results
- Real Madrid: 0 Wins
- RB Leipzig: 0 Wins
- Draws: 0
This will be the first competitive meeting between Real Madrid and RB Leipzig.
Current Form (Last Five Games)
- Real Madrid: WWWWW
- RB Leipzig: WWLLW
Real Madrid team news
Karim Benzema and Eder Militao remain sidelined but Carlo Ancelotti is hopeful that both will be fit enough to return for the upcoming Madrid derby.
Lucas Vazquez also misses out through injury but Alvaro Odriozola has passed a late fitness check and makes the squad.
Real Madrid predicted lineup vs RB Leipzig
Real Madrid Starting 11 (4-3-3): Courtois; Carvajal, Rudiger, Alaba, Mendy; Modric, Tchouameni, Kroos; Valverde, Rodrygo, Vinicius
Bench: Lunin, Lopez, Nacho, Vallejo, Odriozola, Ceballos, Camavinga, Hazard, Asensio, Mariano
RB Leipzig team news
Lukas Klostermann and Dani Olmo are both out for Marco Rose's side, while key midfielder Konrad Laimer has recently been ruled out with an ankle problem.
Rose is still trying to figure out his best side but may be reluctant to move too far away from the setup that thumped former employers Borussia Dortmund.
RB Leipzig predicted lineup vs Real Madrid
RB Leipzig Starting 11 (4-2-3-1): Gulacsi; Simakan, Orban, Diallo, Raum; Kampl, Schlager; Nkunku, Forsberg, Szoboszlai; Werner
Bench: Blaswich, Nickisch, Gvardiol, Halstenberg, Henrichs, Haidara, Novoa, Poulsen, Silva
Real Madrid vs RB Leipzig score prediction
Leipzig were mighty impressive last time out against Dortmund, but replicating that against this Real machine is a different test.
Ancelotti's side have looked unstoppable of late but concerns over their inability to cope without the injured Benzema are more than fair. They made hard work of their four-goal haul against Mallorca at the weekend, but the fact they still managed to score so many served as a real warning sign.
It might not be a vintage Real performance, but it should be enough to get the job done.
Prediction: Real Madrid 2-0 RB Leipzig