Real Madrid have confirmed a Covid-19 outbreak at the club with Marco Asensio, Gareth Bale, Andriy Lunin, Rodrygo and assistant manager Davide Ancelotti all returning positive tests.
The news comes after Luka Modric and Marcelo tested positive for Covid-19 on Wednesday.
This takes the total coronavirus cases at Santiago Bernabeu to seven, leaving Carlo Ancelotti with a weakened squad for his side's last two games before the winter break.
Los Blancos are scheduled to take on Cadiz on Sunday before facing Athletic Club on Wednesday evening. A postponement seems unlikely at this stage as Real still have enough players available to fulfil the fixtures. However, the situation is developing daily.
The absences of Asensio and Rodrygo are set to be the most damaging. The former has reemerged as a dangerous attacking option under Ancelotti after several years in the wilderness.
Meanwhile, Rodrygo has featured fairly regularly this season, making 20 appearances in all competitions.
Coronavirus cases are soaring across Europe due to the emergence of the easily-transmissible Omicron variant, with the Premier League being severely affected in recent weeks.
A handful of fixtures have already been postponed due to Covid-19 outbreaks and the situation is not expected to settle down in the lead-up to the festive period.