RB Leipzig kick off the post-Jesse Marsch era with one of the toughest games in European football - Premier League champions Manchester City.
City have already secured top spot in Champions League Group A and unless Club Brugge can get an unlikely point or better against Paris Saint-Germain, RB Leipzig should finish third and head into the Europa League.
Here is everything you need to know about Tuesday's game...
How to watch RB Leipzig vs Man City on TV/live stream
When is kick off? Tuesday 7 December, 17:45 (GMT)
Where is the match being played? Red Bull Arena
TV channel/live stream? BT Sport (UK), TUDN (US), DAZN (Canada)
Highlights? BT Sport YouTube Channel
Referee? Sandro Schärer
VAR? Fedayi San
RB Leipzig team news
Interim RB Leipzig manager Achim Beierlorzer will welcome Tyler Adams back into the fold with his suspension served, however fellow midfielders Illaix Moriba and Amadou Haidara - supposedly a Man Utd target - are not available.
These are not the only first-teamers out either. Yussuf Poulsen, Dani Olmo, Marcel Halstenberg and Marcelo Saracchi are all injured. Willi Orban and Hugo Novoa are both isolating too.
Man City team news
Pep Guardiola has close to a full squad to choose from, with Ferran Torres his only notable injury concern heading into this one.
As always, rotation is likely, particularly with top spot already in the bag.
Check out Man City's predicted lineup here
RB Leipzig vs Man City head-to-head record
RB Leipzig were only formed in 2009, so you will not be surprised to hear that these two sides' only previous meeting was the reverse fixture on matchday one.
You likely remember that one, it did finish 6-3 after all. Christopher Nkunku bagged a hat trick for Leipzig while six different scorers found the net for City.
RB Leipzig vs Man City score prediction
Barring something remarkable happening in Paris, these two sides will be finishing in the same places they are now by the end of matchday six.
With the pressure pretty much off, and RB Leipzig possessing a fairly relaxed approach to defending at the best of times, expect to see plenty of goals in this one.
City's returning crop of creative midfielders: Phil Foden, Kevin De Bruyne and Jack Grealish, will all be desperate to impress here and so will Leipzig's forwards - who have a new manager to wow following Marsch's departure.
Prediction: RB Leipzig 2-4 Man City