Rangers' run of 40 league games without defeat has come to an abrupt end after they were beaten 1-0 by Dundee United on Saturday afternoon.
This week has already been a tough one for Steven Gerrard's side after they were beaten 2-1 by Swedish side Malmo in the first leg of their Champions League third qualifying round tie on Tuesday.
The Gers returned to league action on Saturday with a trip to Tannadice to face Dundee United, a side they took maximum points off in all of their three meetings last season.
Despite dominating the contest and enjoying 68% possession, Rangers suffered a shock defeat in just their second league outing of the 2021/22 campaign, with Jamie Robson's second-half strike enough to earn all three points for Tam Courts' side.
Gerrard's men struggled to create any massively clear-cut chances throughout, mustering just two shots on target - the same amount managed by the home side - as they failed to break down the stubborn Dundee United backline.
The result comes as a huge shock considering Rangers' domination of the Scottish Premiership last season, with the eventual champions going unbeaten for the entire league campaign and dropping just 12 points in their 38 league outings.
Gerrard will no doubt be keen to stress to his players that the result is by no means a season-defying moment, but news of their defeat will undoubtedly provide a shot in the arm for city rivals Celtic.
Ange Postecoglou has a huge task on his hands at Celtic Park after the Bhoys finished a whopping 25 points behind Rangers in last season's Scottish Premiership, but seeing their rivals' unbeaten run come to an end will definitely offer them encouragement.
Celtic host Dundee on Sunday afternoon as they look to bounce back from their opening day defeat to Hearts at Tynecastle.