Pumas UNAM and the Seattle Sounders go head-to-head in Mexico City on Wednesday night in the first leg of their Concacaf Champions League final clash.
The Liga MX side have never won this tournament since its rebrand in 2008, but did pick up three titles between 1980 and 1989.
As for the Sounders, they're looking to become the first MLS team to lift the trophy since that aforementioned rebrand, following runner-up finishes from LAFC, Real Salt Lake, CF Montreal, and Toronto FC in the past.
The game won't be decided on Wednesday night with the second leg heading to Lumen Field next week, but the stage will be set and we could be in for a fiery encounter.
Read on for Pumas UNAM vs Seattle Sounders team news, broadcast info, predictions, and more:
How to watch Pumas vs Seattle Sounders on TV/live stream
When is kick-off? Wednesday, 27 April, 10:30pm (EST)
Where is it being played? Estadio Olímpico Universitario, Mexico City
What TV channel is it on? Fox Sports 1, TUDN USA, Fox Spors Cono (Mexico)
Highlights? Concacaf YouTube channel
Pumas team news
Juan Ignacio Dinenno and Leonel López have both missed training recently with respective muscle and ankle injuries and remain doubtful for the first leg. Arturo Ortíz Martínez is also missing through suspension after picking up a red card in the first leg.
Pumas predicted XI: Talavera; Mozo, Galindo, Freire, Velarde; Islas, Meritão, De Olivera, Rodríguez; Álvarez, Coroz.
Seattle Sounders team news
Goalkeeper Andrew Thomas has a calf injury but would only have warmed the bench anyway. Yerai Gomez came off the bench against San Jose at the weekend and could start. Brian Schmetzer has all of his big names available for this crucial away leg.
Seattle Sounders predicted XI: Frei; A. Roldan, Ragen, Arreaga, Nouhou; Joao Paulo, C. Roldan; Rusnak, Lodeiro, Morris; Ruidiaz.
Pumas vs Seattle Sounders head-to-head record
This is the first competitive meeting between these two teams.
Pumas have already knocked out MLS opposition in this year's Champions League, beating the New England Revolution in the quarter-finals. Likewise, the Seattle Sounders beat Liga MX's Club Leon at the same stage.
Pumas vs Seattle Sounders score prediction
This isn't the game that decides the tie, but it could leave one of these teams with a mountain to climb in the second leg.
As the hosts, the onus will be on Pumas to play on the front foot on Wednesday which will seriously test the Sounders' backline, but also leave space for the likes of Jordan Morris, Albert Rusnak, and Raul Ruidiaz, who are ruthless in transition.
Expect an entertaining game with the Sounders in some form of control heading back home.
Prediction: Pumas UNAM 2-2 Seattle Sounders