Chelsea's London derby with Tottenham at Stamford Bridge is the standout fixture of the weekend, but don't take your eyes off Crystal Palace's clash with Liverpool – the latter has proven in the past that could be a real barnstormer.
Norwich started things off on Friday night with a statement win in their relegation six-pointer, while Lucas Digne had the last laugh against former club Everton. Manchester United and Newcastle also secured vital wins with late goals on Saturday, while Southampton frustrated Manchester City.
Friday 21 January
Norwich picked up a huge 3-0 win against relegation rivals Watford on Friday night, with goal-shy striker Josh Sargent netting twice.
Sargent got the party started with a stunning scorpion kick just before the break and he rose high at the back post to make it 2-0 with 16 minutes of normal time remaining.
Things soon got worse for Watford as Emmanuel Dennis saw red for a second booking, and the Canaries impressive win was capped off with a Juraj Kucka own goal in second-half stoppage time.
Saturday 22 January
Emiliano Buendia scored the only goal of the game as Aston Villa picked up all three points against manager-less Everton, who parted company with Rafa Benitez last week.
Ex-Toffess star Lucas Digne got the assist for the decisive goal, which came in first half stoppage time. But both he and teammate Matty Cash were struck by a projectile thrown from the Goodison Park crowd during the celebrations - an arrest was made by police.
Wolves secured an away victory against Brentford thanks to a second half winner from Ruben Neves, which restored his team’s advantage after Ivan Toney had cancelled out Joao Moutinho’s opener.
The first half was paused twice, once so that could treatment could be given to Brentford pair Mathias Jensen and Rico Henry following a sickening clash of heads, and later because there was a drone flying over the pitch.
Adama Traore thought he had made it 3-1 in the closing stages but VAR intervened.
Newcastle managed only a second Premier League win of the season, beating Leeds at Elland Road and rising to within one point of safety – with a game in hand on Norwich above them.
Jonjo Shelvey’s free-kick from the edge of the penalty area made the crucial difference with around 15 minutes left to play.
It was a blow for Leeds, although Marcelo Bielsa’s team at least have the benefit of a seven-point cushion between themselves and the drop zone.
Manchester United had to wait until the 93rd minute to made the breakthrough against West Ham at Old Trafford, with Marcus Rasford turning home Edinson Cavani’s low cross a few yards from goal.
The hosts had the majority of the possession and peppered the West Ham goal with shots, most of which missed the target. The Hammers were always in the game and did have chances of their own through Jarrod Bowen and Tomas Soucek.
But the decisive blow came right at the end. Anthony Martial, who got a mixed reception off the bench, played in Cavani, who in turn found Rashford.
Southampton stopped Manchester City from making it 13 consecutive Premier League wins with a 1-1 draw at St Mary’s.
Kyle Walker-Peters gave the Saints an early lead with his first ever Premier League goal. Armando Broja also had the ball in the net but was denied by an offside flag and later hit the post.
City weren’t at their best but improved as the game progressed and eventually got back on level terms when Aymeric Laporte headed in from a set-piece.
Sunday 23 January
Arsenal fell to a disappointing goalless draw against struggling Burnley at the Emirates Stadium.
The Gunners dominated possession throughout the contest but could not beat Nick Pope in the Clarets' goal.
Alexandre Lacazette and Emile Smith Rowe had the host's best chances but neither could convert. The point is a vital one for Burnley but they remain rooted to the bottom of the Premier League, albeit with several games in hand over the sides above them.
Liverpool trimmed Man City's lead at the top of the Premier League table to nine points with a 3-1 win over Crystal Palace at Selhurst Park.
The Reds started brilliantly and raced into a two-goal lead courtesy of a Virgil van Dijk header and Alex Oxlade-Chamberlain strike. However, Palace responded brilliantly and deservedly drew level through Odsonne Edouard in the second half.
The Eagles continued to threaten before a controversial penalty decision allowed Fabinho to put the game beyond the hosts from 12 yards.
Leicester suffered late heartbreak for the second successive game with Danny Welbeck earning Brighton a point at the death on Sunday.
Both sides could have scored in the first half but it took until the 46th minute for deadlock to be broken with Patson Daka converting a typical poacher's effort.
Brighton responded well to going behind though, and got their reward eight minutes from time when Welbeck rose high at the back post to secure the draw.
A wonderful goal from Hakim Ziyech lit up a feisty London derby in which Chelsea ran out 2-0 winners over Tottenham.
The Blues had the better chances in the first half but were fortunate to go into the break level after Harry Kane had an effort controversially chalked off.
Chelsea took the lead two minutes after the interval with Ziyech whipping an unstoppable effort into the top corner. Thiago Silva then made sure of the points by flicking a header past Hugo Lloris.