Arsenal vs Manchester United, Liverpool vs Everton, Chelsea vs West Ham - the three headline games as the Premier League marches on towards the end of the season.
It's still all to play for wherever you look; Manchester City and Liverpool doing battle for the title, Tottenham, Arsenal and Manchester United contending for a top four finish and Champions League berth, and Burnley, Everton and Leeds scrapping for their Premier League lives (sorry Norwich and Watford).
Gameweek 34 comes hot off the heels of a number of sides playing twice within the space of a few days, so results this weekend could be determined by who has the most gas left in their flagging tank.
Here's 90min's predictions for what's ahead, as well as links to full match previews across the board.
Arsenal vs Manchester United
The opening game of the weekend pits Arsenal against former arch energy Manchester United, though the days of these two contesting the Premier League title are long gone.
Mikel Arteta's Gunners come into the fixture in positive mood, having turned over Chelsea in midweek, but the same can't be said for Ralf Rangnick's United - they were tossed aside by a rampant Liverpool during a dismal 4-0 defeat at Anfield.
Can the appointment of Erik ten Hag as manager for next season galvanise the Red Devils? Don't count on it.
Leicester vs Aston Villa
It could be an exciting end to the season for Leicester, with an appearance in the maiden final of the Europa Conference League now a distinct possibility.
Brendan Rodgers's side won't rest on their laurels though and will fancy their chances of downing an Aston Villa side who have lost their last four. Steven Gerrard's tenure has actually been a bit underwhelming all things considered - they've lost 11 of their 21 games under him - but they remain capable of scoring goals.
Leicester are also very capable of conceding them, which could make this a good watch.
Manchester City vs Watford
Is anybody outside of Manchester City and Liverpool circles actually excited about the Premier League title race? That remains to be seen, but one thing that is for sure is that struggling Watford are the next side in the firing line of Pep Guardiola's winning juggernaut.
Brighton were swept aside by an under-par City in the week, and there's no reason to think that the Hornets - who are looking like relegation dead certs - will be able to fare any better.
Norwich vs Newcastle
Whisper it quietly but Eddie Howe is doing a bloody good job in the North East, despite many feeling that keeping Newcastle up was near impossible when he took over.
The Magpies are on the cusp of the Premier League's top ten after notching their sixth home win in a row up during midweek, but the same can't be said for Norwich - with Dean Smith's side appearing ready to board the first train back to the Championship.
To keep their faint survival hopes alive, Norwich must win here - but it's hard to see them doing it.
Brentford vs Tottenham
All eyes will be on Christian Eriksen this Saturday evening as the Dane lines up for Brentford against the club he served so well for seven years.
Tottenham's visit to west London is also another chance to demonstrate their top four credentials, which were damaged by the surprise defeat to Brighton last Saturday.
In Harry Kane and Son Heung-min though, Antonio Conte has two players who love scoring in London derbies - something that should give him great confidence against Thomas Frank's resurgent Bees.
Listen now to 90min's brand new podcast, Talking Talking Transfers, with Scott Saunders & Graeme Bailey. Toby Cudworth joins the show this week to discuss contract situations at West Ham, while there are updates on Man City's pursuit of Erling Haaland and Chelsea's plans for Romelu Lukaku.
Brighton vs Southampton
It's been a pretty good couple of weeks for Brighton after back-to-back wins in north London over Tottenham and Arsenal prepared them for inevitable defeat to Manchester City on Wednesday.
The same can't be said for Ralph Hasenhuttl's Southampton, who continue to be anything but consistent. A dismal showing against Burnley on Thursday showed how bad the Saints can be when they're off their game, and it'll take something special to get them in the right frame of mind - because of how they bad were - for a trip to the south coast.
Burnley vs Wolves
Burnley's clash with Wolves at Turf Moor won't be the most glamorous game of the weekend but it could turn out to be the most important.
The Clarets have a bit of added fire in the belly, perhaps owing to Sean Dyche's dismissal, and put in a terrific performance to beat Southampton on Thursday and close the gap on relegation rivals Everton.
Wolves' recent pattern of results suggests they either win or lose, and Bruno Lage will be desperate for the former to keep the club's Europa League qualification hopes alive. Whether they get it is another story.
Chelsea vs West Ham
Surprised to see Arsenal run out 4-2 winners at Stamford Bridge on Wednesday? Mmm, 90min was as well - although the warning signs suggesting Chelsea are capable of such meltdowns have been there for all to see of late.
Opponents West Ham are still chasing a top six finish - although they will still dream of top four - but have the added distraction of a Europa League semi-final to contend with. Their record away from home against the big boys isn't great either, meaning it could be another blue day in west London despite Chelsea shedding goals for fun of late.
Liverpool vs Everton
Jurgen Klopp's Liverpool are in sensational form while Frank Lampard's Everton are, well, not.
The Reds come into the Merseyside derby firing on all cylinders after the midweek thrashing of Manchester United, whereas the Toffees were thankful for Richarlison's stoppage-time goal rescuing a point against Leicester.
It's hard to overlook a home win here despite it being a derby, and you can expect it to be a comfortable one at that.
Crystal Palace vs Leeds
There's not much left to play for if you're a Crystal Palace fan, with Premier League safety pretty much guaranteed unless something goes disastrously wrong between now and the end of the season.
The same can't be said for Jesse Marsch's Leeds just yet, who know they must pick up a least couple of wins between now and the end of the season. Two good teams who play expansive football can only mean one thing in the goals department, surely...