Ole Gunnar Solskjaer has confirmed both Anthony Martial and Edinson Cavani suffered injuries during Manchester United's 3-1 win over West Ham on Saturday.
United were 1-0 down at the break before Bruno Fernandes and Marcus Rashford were introduced. Paul Pogba, Mason Greenwood and Rashford grabbed the goals to secure a 3-1 win, with the result moving the Red Devils up to fifth, just three points adrift of leaders Chelsea.
However, it wasn't all good news. At the break, Cavani was withdrawn, while Martial pulled up with a problem early on in the second half.
Speaking after the victory, Solskjaer told MUTV: "We lost Anthony and Edinson. Hopefully they aren't too bad but they couldn't carry on today. There's a game coming up on Tuesday but that's probably going to be the season this year.
"There's going to be some games that we have to do without players and I'm glad we've got the subs that we have. They're not bad ones hopefully. We'll do scans and hopefully they'll be available soon."
Their injuries come on the eve of United's most important game of the season so far against RB Leipzig. Going in their final Champions League group stage fixture, United know that avoiding defeat to Julian Nagelsmann's side would guarantee qualification into the knockout stages.
Solskjaer said he hoped that their win over the Hammers would help give them momentum for Tuesday's game.
"It's a brilliant week. We're looking forward to it. That's a good start," he added.
Cavani and Martial will not be the only players missing for the Leipzig game. David de Gea is also struggling for fitness and could miss out, while Luke Shaw remains on the sidelines with a hamstring problem.