Liverpool manager Jurgen Klopp has opted not to risk Mohamed Salah from the start against Arsenal, with the Egyptian struggling with a foot injury picked up the 2-0 win over Brighton on Saturday.
Salah bagged his 20th goal of the Premier League season to help the Reds pick up another three points on the road, but his afternoon was curtailed by a foot problem just after the hour mark.
It was hoped that Salah would recover in time to start against Mikel Arteta's in-form Arsenal, but Klopp has instead gone with the trio of Luis Diaz, Sadio Mane and Diogo Jota up front - hardly a drop off in quality.
Thiago sits alongside captain Jordan Henderson and Fabinho in a midfield three, with Liverpool's first choice back four of Trent Alexander-Arnold, Joel Matip, Virgil van Dijk and Andrew Robertson sitting in front of goalkeeper Alisson. Salah, meanwhile, is on the bench and could feature in the second half.
Arsenal are unchanged from the side that beat Leicester 2-0 at the Emirates Stadium on Sunday, with Mikel Arteta's hoping to extend their advantage over Manchester United, West Ham, Wolves and Tottenham in the race for a top four finish.
Alexandre Lacazette starts up front, supported by Bukayo Saka, Martin Odegaard and Gabriel Martinelli, with Ben White and Gabriel tasked with keeping Diaz, Mane and Jota at bay.