Marcus Rashford has been ruled out of England's three World Cup qualifiers with an ankle injury and will return to Manchester for his recovery.
The Manchester United forward had been a doubt for Thursday evening's clash with San Marino, having sat out training with the squad as he nursed an ankle problem sustained at the beginning of March.
England play Albania on Sunday and Poland the following Wednesday as their bid to reach the 2022 Qatar World Cup gets underway.
He missed United's Europa League last 16 first leg against Milan before playing the following week against West Ham. However, the forward was then forced off at half time against Milan in the return leg and sat out the Red Devils' recent FA Cup defeat to Leicester.
Rashford is not said to have suffered ligament damage, rather just bruising and swelling on the foot and bleeding on the bone.
Having missed England's last international camp in November, the 23-year-old joined up with England in order to take part in team meetings and be a part of the squad ahead of this summer's European Championship. However, he will now return to Manchester to complete his recovery.
Rashford's United teammate Mason Greenwood also dropped out of the England Under-21 squad on Wednesday due to injury and was replaced by Todd Cantwell.
It is not yet known whether Gareth Southgate will select a replacement for Rashford, but the England manager did hint during his first press conference ahead of the upcoming camp that Leeds forward Patrick Bamford could be in line for a call up should his forward line be hit by injuries.