The Red Devils entered the international break off the back of an impressive 3-1 win against Carlo Ancelotti's Everton and the visit of the Baggies offers an opportunity to build on that result and rise up the table.
Slaven Bilic's side, meanwhile, are without a win in their first eight Premier League matches. The Midlands club achieved promotion last season but have found the transition to the top flight tough so far.
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Marcus Rashford is a doubt due to the same shoulder issue that forced him to leave the England squad, while fellow forward Mason Greenwood is suffering from an illness. A decision on whether he features or not will be left until the last minute.
Luke Shaw is a long-term absentee with a hamstring injury, but Brazil international Alex Telles could replace him at left back after recovering from coronavirus. Paul Pogba and Donny van de Beek have impressed for their respective countries and will be pushing to feature from the first whistle, with Ole Gunnar Solskjaer having an abundance of options in the engine room.
West Brom trio Callum Robinson, Branislav Ivanovic and Matheus Pereira have all been self-isolating for the last ten days after they returned positive COVID-19 tests earlier this month. If they return negative tests before the match, they could be set to feature in the starting XI.
The weekend encounter will come too soon for Sam Field, who is nursing a knee injury, and Hal Robson-Kanu, who suffered a broken arm last month.
Manchester United: De Gea; Wan-Bissaka, Lindelof, Maguire, Telles; Fred, McTominay, Fernandes; Rashford, Martial, Greenwood.
West Brom: Johnstone; Ivanovic, Ajayi, Bartley, Gibbs; Townsend, Gallagher, Livermore, Krovinovic, Robinson; Grant.
Solskjaer's side are currently 14th in the Premier League table, having lost three of their opening seven fixtures. Their Champions League form helped gloss over the cracks before some amateur defending resulted in a 2-1 loss to Demba Ba's Istanbul Basaksehir.
However, United did bounce back from that shock defeat in Turkey with an impressive display at Goodison Park. Despite falling behind to a Bernard strike, the Red Devils turned things around and ran out comfortable winners in Merseyside.
West Brom have made a slow start to life back in English football's top tier. They've only picked up three points from a possible 24 and have conceded the most amount of goals along with Leeds.
Summer signing Karlan Grant leads the Baggies' hopes for survival. The former Huddersfield man found the back of the net against Brighton last month to rescue a point and he'll need to strike on a regular basis if they're to stand any chance of staying up.
Here's how the two sides have fared in their last five fixtures.
West Brom 0-1 Tottenham (8/11)
Fulham 2-0 West Brom (2/11)
Brighton 1-1 West Brom (26/10)
West Brom 0-0 Burnley (19/10)
Southampton 2-0 West Brom (4/10)
United have failed to find consistent form so far this season and could be without some key names for this Saturday night clash, but Solskjaer will still be confident his side can record a routine victory.
West Brom have been leaking goals with alarming regularity without scoring too many at the other end, which is always a treacherous combination, although Bilic's men do have some quality within their ranks, especially going forward.
The Red Devils on their home patch should have too much for the Baggies and will most likely come away with the three points.
Prediction: Manchester United 2-0 West Brom