Jordan Nobbs will miss the remainder of the WSL season due to the injury she sustained during Arsenal's 7-0 victory over Aston Villa on Sunday.
The all-action midfielder has not yet been ruled out of participating at Euro 2022 and will continue to be assessed - the tournament kicks off at Old Trafford on 6 July.
Nobbs was a second half substitute during the Gunners' win over Aston Villa, but was replaced within 10 minutes of entering the fray after appearing to pick up a knee injury. She left the pitch in tears, making a point of clapping the Arsenal faithful as she departed.
"Initially when we scanned it, unfortunately she is going to miss the rest of the season with Arsenal," said manager Jonas Eidevall. "But it is an injury with ongoing assessment here with consultants during the week, and we will know more after they have looked at it and we have to wait and see.
"I know it's a frustrating answer, but it's of course so frustrating for us and mostly for Jordan not being able to participate here at the end of the season and we can just hope it's as good as possible."
Renowned for her energetic style and ability to find the net from all over the pitch, Nobbs is considered one of the finest midfielders England have produced over the last decade, but has endured rotten luck with injuries over the course of the last seven years.
The 29-year-old was restricted to just one appearance at the 2015 World Cup due to a hamstring tear suffered weeks before the tournament kicked off, and missed out on a spot in the England squad that travelled to France four years later after rupturing her ACL.
She was one of a number of big names to not be included in Team GB's Tokyo Olympic squad last summer, alongside Arsenal teammate Beth Mead and Manchester City's Alex Greenwood.
Prior to suffering an ACL injury in November 2018, Nobbs had been in the form of her life, netting nine goals during the first eight matches of the 2018/19 campaign as Arsenal went on to win their first WSL title in seven years.
She has played more of a peripheral role under Eidevall this season and has not started in the WSL since January, with Lia Walti, Kim Little and Vivianne Miedema, who has dropped into a deeper role, currently the Gunners' favoured midfield three.