Inter could be without Lautaro Martinez and Alexis Sanchez for their top-of-the-table Serie A clash against Napoli on Sunday.
Gli Azzurri go into the game seven points clear of their opponents in third, and level with second-place Milan.
Defeat for Inter would represent a damaging blow to their hopes of retaining the Scudetto and they could have to get the job done without some of their best players.
In the most worrying news, Martinez was forced off at half time during Argentina's 0-0 draw with Brazil, which confirmed his side's qualification for the World Cup next winter. The forward was on the end of several strong challenges throughout the contest and will be assessed upon his return to Italy.
Martinez has been ever-present in the Inter side this season, making 15 appearances in all competitions and scoring five goals.
Meanwhile, Sanchez also suffered injury trouble while on international duty with Chile. The former Arsenal man was taken off just after the half-hour mark as his side fell to a damaging 2-0 defeat against Ecuador.
Sanchez has not always started this campaign but he has provided some important contributions from the bench and his possible absence would be a significant blow ahead of such a big game.
In better news, Martinez's strike partner, Dzeko, should be okay to feature on Sunday. The 35-year-old did not represent Bosnia & Herzegovina this month due to a thigh problem sustained in the Derby della Madonnina before the international break.
However, even though he is still training alone, Gazzetta dello Sport (via SempreInter) have reported that he should be back in time for the clash.
Nicolo Barella - who was also injured in the Milan derby - will be fine too, after featuring for Italy in both of their recent internationals.
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