City have only recently welcomed Riyad Mahrez and Aymeric Laporte back to training after the pair were also diagnosed with the virus and forced into a ten-day period of self-isolation.
The club took to their official website to confirm Gündoğan has already entered his own self-isolation period, meaning he could miss City's next four fixtures in all competitions.
After Monday's meeting with Wolves, City are scheduled to face Bournemouth in the Carabao Cup on Thursday before returning to league action with the visit of Leicester City on Sunday. Gündoğan may be available to return to training after that, but whether he will be ready for the meeting with Leeds United on October 3 remains to be seen.
Losing Gündoğan will come as a huge blow to Pep Guardiola, who is hoping to see his side bounce back from their disappointing 2019/20 season with an impressive start to the new campaign.
“Last season we scored the most goals and Ederson got the Golden Glove for most clean sheets, but we still need to improve because we lost too many games,” Gündoğan said (via The Guardian) before being diagnosed with the virus.
“Some games we would win comfortably, then in others we would make a mistake or not finish our chances and lose. It is impossible to win every game but what you can do is try to learn from your defeats.
"We have to try to be more consistent in all the games. It is hard to rack up 100 points or 98 points every single year, but if we want to be challenging for all the titles again this season we have to be closer to that sort of standard.
“We shouldn’t be looking to completely change the way we do things, because we have a certain way of playing that has worked well for us in the past, but there are small things we can improve on if we want a better season than last year.”