England manager Gareth Southgate says he is unsure of the severity of Joe Gomez's knee injury - but admitted the Liverpool defender was 'in a fair bit of pain'.
Gomez has been ruled out of the Three Lions' three fixtures against Ireland, Belgium and Iceland during November's international break after sustaining a potentially serious knee injury in training on Wednesday.
The centre back will undergo a diagnosis with the Liverpool medical team, and Southgate admitted he was currently unsure of the extent of the injury.
"I can't tell you how serious it is because he is yet to have scans" said Southgate [via Sky Sports]. "What was upsetting was to see he was in a fair bit of pain, and the fact there was nobody around him when the injury happened.
"We just have to wait and see what the scans show, and we are all hopeful for him that it is not what it might be. But it's not a good situation. I don't see him being involved in the games with us, that's for sure.
"My immediate thoughts are with him because he's had some difficulties with injuries with him in the past. So we are praying it's not going to be a long-term one. But we just have to see."
Gomez's injury is a further blow to Liverpool, who are already without influential centre back Virgil van Dijk after the Dutchman suffered a potential season-ending knee injury against Everton in October.
Right-back Trent Alexander-Arnold is also primed for a spell on the sidelines with a calf injury, which is expected to keep him out of action for a month.
Defensive midfielder Fabinho - who had impressed in the heart of the Liverpool backline in Van Dijk's absence - sustained a hamstring injury against Midtjylland, but this is not as serious as initially feared and the Brazilian could return after the international break.