Leicester City will welcome Manchester United to the King Power Stadium in one of the top picks of the FA Cup quarter-final draw.
Both Brendan Rodgers and Ole Gunnar Solskjaer will be keen to advance to the last four of the competition, with neither boss having secured a maiden piece of silverware at their respective clubs since their arrivals.
The two sides have already met at the King Power this season, with the Foxes ending United's 100% away record in this season's Premier League during an entertaining 2-2 draw.
Elsewhere, Manchester City face a tough trip to Everton after the Toffees dispatched of Tottenham in a pulsating 5-4 win at Goodison Park in the fifth round.
Pep Guardiola's side were dumped out of the competition at the semi-final stage last season by eventual winners Arsenal, and a victory over Carlo Ancelotti's side will afford them the opportunity to go one better than their efforts in the 2019/20 campaign.
Ralph Hasenhüttl's injury-ravaged Southampton side will make the short journey to fellow south coast side Bournemouth.
The tie represents a glorious opportunity for the Cherries to book their place in the last four of the competition, with the club enjoying a dramatic upturn in form since the arrival of Jonathan Woodgate as interim boss.
Chelsea, who beat Barnsley 1-0 on Thursday night, have a home tie against the Premier League's bottom side Sheffield United. The Blues are now just three wins away from lifting the FA Cup and going one step further than Frank Lampard's beaten finalists of 2019/20.
Quarter-final draw in full
Everton vs Manchester City
Bournemouth vs Southampton
Leicester City vs Manchester United
Chelsea vs Sheffield United
All ties will take place on the weekend of Saturday 20 March 2021, with the winning clubs pocketing £360,000 for reaching the last four.