Leicester's Premier League trip to Everton on Tuesday has been postponed with the Foxes unable to submit a squad of enough players to fulfil the fixture.
The decision comes after both clubs met with the Premier League Board on Sunday evening, with the fixture cancelled for a second time following its initial postponement on December 19.
Brendan Rodgers is without the majority of his first-team squad due to positive Covid-19 tests, injuries and players away at the Africa Cup of Nations.
A Premier League statement read: "The Board was able to make its decision in advance of the fixture to give clarity to the affected clubs and their fans. We apologise for the inconvenience and disruption caused to supporters who planned on attending and watching the game, and we are aware that postponements will disappoint fans.
"The League aims to provide as much clarity as possible, but unfortunately postponements sometimes have to be made at short notice, as safety is our priority. Where possible, the League will endeavour to keep supporters updated if games become at risk on a matchday.
"The Board assesses applications to postpone matches on a case-by-case basis, based on existing rules and adapted COVID-19 postponement guidance, implemented in light of the new Omicron variant. The Board will assess a number of factors, including the ability of a club to field a team; the status, severity and potential impact of the COVID-19 outbreak at the club; and the ability of the players to safely prepare for and play the match. The Board must also consider the wider risks to the opposition and other people the club representatives may come into contact with.
"Click here to read the updated guidance on the Premier League’s match postponement process."