EFL clubs have voted to allow five substitutions per game for the remainder of the 2020/21 season.
Additional changes have already been sanctioned across Europe with the Premier League now one of few divisions still only permitting three.
The EFL announced the news in a statement posted on their official website.
"Following consultation with Clubs, the EFL Board has agreed to increase the permitted number of substitutes to five in all Sky Bet EFL fixtures taking place from 12 noon on Friday 20 November for the remainder of the 2020/21 season," it read.
The statement added that Championship clubs would be permitted to name up to nine substitutes in their matchday squads, while League One and League Two sides would be restricted to seven.
Back in September, Premier League sides held a similar vote, with the motion to allow five alterations during a game being soundly rejected. The temporary measure was brought in as part of Project Restart last season but smaller clubs are understood to have voted against its continuation over fears that it favours the Big Six.
With more games being postponed due to coronavirus outbreaks within clubs, the FA, Premier League, EFL & Women's Super League have announced stricter guidelines
Premier League and EFL clubs are including covid clauses in loan deals and new contracts for new and existing players to protect themselves.
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The decision was criticised by Manchester United boss Ole Gunnar Solskjaer last month, who called for greater consideration for player safety.
"I can see why clubs voted against but if you take a step back and think about these professional footballers and their mental and physical health, the only sensible solution would have been to give us the opportunity to rest a few more," he said.
Liverpool and Manchester City managers Jurgen Klopp and Pep Guardiola also spoke out after their side's met last week. Both argued that not having five subs was increasing the risk of players getting injured - despite neither manager using all three changes available to them during the game.