West Ham have confirmed three new cases of COVID-19 at the club, including manager David Moyes.
Defender Issa Diop and midfielder Josh Cullen were the other two who received positive results less than a hour before the start of their Carabao Cup tie with Hull City on Tuesday evening.
The contest went ahead with Moyes' assistant Alan Irvine taking charge and both players - who were named in the Scot's starting XI - withdrawn immediately.
An official club statement read: "West Ham United can confirm that David Moyes, Issa Diop and Josh Cullen have returned positive tests for COVID-19.
"The club’s medical team were informed of the test results as the team were at London Stadium preparing for this evening’s Carabao Cup third round tie against Hull City. The manager and both players immediately left the stadium and have returned home.
"All three, who are asymptomatic, will now follow Public Health England and Premier League guidelines and protocols.
"The club’s measures and protocols around COVID-19 remain stringent. This included offering to test the Hull City team ahead of tonight’s [Tuesday] fixture – an offer which they opted not to accept."
Amid fears of a second wave of coronavirus hitting the UK, Leyton Orient's cup tie with Tottenham was postponed after the League Two outfit returned a number of positive tests - which were paid for by the Premier League club.
It's understood that over ten Orient players tested positive in the wake of their 2-2 draw with Mansfield on Saturday.
As for the Hammers, government guidelines mean Moyes won't be in the dugout for their upcoming Premier League clash with Wolves on Sunday.
The trio will be forced to self-isolate for ten days after being sent home from the London Stadium on Tuesday night. Moyes could return to the Hammers bench for their trip to Leicester on 3 October, while the two players will be available for selection.