Atletico Madrid will return to Manchester on Tuesday for a battle with the blue side of the city.
Diego Simeone's men knocked United out of the Champions League in the last round and must now dance with Manchester City for a spot in the semi-final.
There are a few injury and suspension issues for the boss to contend with, so here's how he could set up.
1. Goalkeeper & defenders
Jan Oblak (GK) - Oblak has been a shadow of his former self this season and really needs to step it up against one of the game's best attacks.
Sime Vrsaljko (RB) - Simeone chops and changes between a three-man and four-man defence. He might prefer more numbers for this one, meaning Vrsaljko is his man.
Mario Hermoso (CB) - A regular earlier in the season before suffering an injury, Hermoso could return to the starting lineup because of Jose Gimenez's absence.
Stefan Savic (CB) - Savic made 21 appearances for City between 2011 and 2012 and has since blossomed into a real anchor for Atletico.
Reinaldo (LB) - A regular since his January arrival, Reinaldo is usually a left-back but could pop up in a back three if Simeone wants.
Marcos Llorente (RM) - Another of those whose position is impossible to predict, we'll go with right midfield for Llorente.
Koke (CM) - Captain Koke has returned from a domestic suspension so should be fit for this one.
Geoffrey Kondogbia (CM) - Simeone may prefer someone more conservative like Kondogbia in his midfield while away from home.
Thomas Lemar (LM) - Yannick Carrasco is suspended so Simeone should turn to Lemar, although he did test Renan Lodi as a winger at the weekend.
Joao Felix (ST) - Felix is flying at the minute and will be one of the first names on the team sheet.
Luis Suarez (ST) - While Antoine Griezmann has been impressive of late, it's hard to see Simeone going with anyone other than Suarez for a game of this size.