Atletico Madrid travel to Catalonia to face Barcelona in a La Liga match that may have lasting repercussions in the race for Champions League qualification.
Diego Simeone's decade-long dynasty at Atletico Madrid has garnered two league titles, multiple European crowns, a Copa del Rey and a pair of Champions League finals, but there remains a notable blindspot: Camp Nou.
Here's the XI Simeone may deploy to earn his first managerial victory at Barcelona's famous stadium after 14 winless trips.
Atletico Madrid predicted lineup vs Barcelona - La Liga
1. Goalkeeper & defenders
Jan Oblak (GK) - The out of form Oblak-tapus hasn't conceded a goal in his last three games against Barcelona.
Daniel Wass (RB) - One of Atletico's two winter arrivals (for a combined fee of a little over £5m), Wass may well begin the task of replacing the output provided by the departed Kieran Trippier this weekend.
Stefan Savic (CB) - A mainstay of last season's title tilt, Savic could be in line for his first league start for two injury-riddled months.
Jose Maria Gimenez (CB) - Across his entire career, Barcelona are the only team that has beaten the former Diego Godin understudy more than three times - in fact, Gimenez has lost seven of his ten meetings with the Catalans.
Mario Hermoso (LB) - While the addition of Lille's Reinildo underlines the lack of faith Simeone has in Renan Lodi, the Argentine coach could opt for the more defensively minded approach Hermoso brings to left back.
Yannick Carrasco (RM) - The subject of an almost insulting deadline day bid from Tottenham Hotspur, the squad's most frequent outfield starter (27 across all competitions) is unlikely to be left on the bench after his services were retained.
Koke (CM) - The club's second-highest all-time appearance maker was almost ripped away from his 'home' at 22 when Barcelona pursued the midfielder in 2014, as Koke later admitted: "It's not easy to say no to Barça."
Rodrigo de Paul (CM) - The most penetrative passer among the squad's regular starters has sacrificed his propensity for a dribble since arriving from Udinese.
Thomas Lemar (LM) - One of the few - if not the only - Atletico players that have improved since the title winning campaign, Lemar has had a hand in more league goals than any other season during his time in Spain already this term (seven - three goals, four assists).
Joao Felix (ST) - The chief villain of Atletico's remarkable stoppage time turnaround against Valencia in the club's last outing - having been removed while trailing 2-0 - Felix may be a beneficiary of the international travel of Atletico's other forwards.
Angel Correa (ST) - Four goals in his last three La Liga outings has helped the scrappy, overlooked Argentine sneak up the standings as Atletico's leading scorer this season (with eight in the league).