There's just one point separating the sides in midtable, but Saturday's hosts come into the match as favourites after winning on the road at West Ham last week, while Bournemouth are without a win since the start of November.
But who's going to come out on top this time around?
Well, here's a handful of Opta stats that should help you make up your mind...
History's on Tottenham's Side
Bournemouth might have won the last time these two sides faces each other - their only win over Tottenham in the Premier League era - but it's Saturday's hosts who can take the most confidence from the history books.
The Cherries have made the journey to the capital on four occasions in the Premier League, but Howe's side are yet to pick up a single point away at Tottenham.
It's not just points that Bournemouth are lacking in north London, as Tottenham have won all four meetings by an aggregate scoreline of 13-0.
Missing Hugo Lloris
Paulo Gazzaniga has done just about enough to keep things ticking over while Hugo Lloris continues his recovery from injury, but Tottenham are still enduring one of their worst defensive records in seven years.
They've kept just one clean sheet in the Premier League this season, which is fewer than any other team in the top flight this season.
It's the first time that Tottenham have only managed one clean sheet from their opening 13 league matches since the 2012/13 season, under
Shoot on Sight
History might be on Tottenham's side, but Bournemouth will be guaranteed to get their chances this weekend in London.
Mourinho still hasn't had quite enough time to implement his infamous 'park the bus' technique just yet, so Tottenham's record of conceding a record number of shots looks set to continue for another week at least.
They've faced 76 shots so far this season -
Set Piece Routines
Bournemouth will be given chances to score from open play this weekend, but it's actually from set-pieces where Howe's counter-attacking side have looked the most dangerous.
They've scored eight goals from set-piece situations (excluding penalties) this season - more than any other side in the Premier League.
And as Bournemouth have only scored 16 goals this season, their ration of 50% of their goals coming from set-pieces is also the highest in the top flight.
Harry Kane Will (Probably) Score
Bournemouth aren't Harry Kane's favourite opponent to play against, but the England international has still scored more than one goal a game against the Cherries in his career.
Kane's played six times against Bournemouth and he's scored seven goals in the process.
Six of those, however, came in Kane's first three appearances against Eddie Howe's side.
The Special One
Saturday's game will be Mourinho's first at home with Spurs in the Premier League, meaning 'The Special One' is at risk of matching Martin Jol's record as the most recent Tottenham boss to lose their first home game.
Tottenham's last five permanent managers are unbeaten when they step out in their first home match (W3, D2), while Jol the last manager to lose his opening match - a 3-2 defeat to Charlton Athletic in November 2004.