While manager Ole Gunnar Solskjaer has denied the need for wholesale changes and urged against a knee-jerk reaction to recent poor results, changes this summer are inevitable.
"I like all these boys, I love them, because they're great lads. But I've got to make a decision, I've got to manage for the club," the Norwegian said last week.
"I'm managing the club, I'm managing the players. I help the players, but I'm managing for the club and I'm going to put all my effort into doing what I think is right for the club."
It had already been reported this week that Pogba has informed teammates he wants to leave and that United won't stand in his way.
The reports earlier in the week claimed that Barcelona wouldn't pursue a deal for Rashford, whose United contract is due to expire in 2020, because the £150m price tag was too high. Now, however, The Sun claims that the Spanish champions are 'confident' of a £100m deal.
Full of transfer clichés, the tabloid report describes Rashford as a 'contract rebel' and alleges that Barcelona are 'considering' bidding £100m for the star and 'ramping up the pressure'. They are said to believe Rashford may not wish to stay without Champions League football.
It still seems a stretch to say that Rashford could be playing his football elsewhere next season, but Sanchez is certainly a player who may actually leave after a disastrous spell in Manchester.
According to The Independent, Inter are ready to offer the Chilean a new home, but only if he is willing to take a pay cut on the enormous £500,000-per-week contract he is currently on.
Cost, age and recent form are said to have killed the market for Sanchez, with Paris Saint-Germain, who once might have jumped at the chance to sign him, said to be no longer interested.
The same report from The Independent notes that Inter are also eyeing a potential move for departing United captain Antonio Valencia, who will be a free agent in June.
A report from SPORT in Spain, suggests that Juan Mata, another on course to leave United on a free transfer at the end of the season, has emerged as a target for Atletico Madrid. The 2010 World Cup winner hasn't played for a club in his home country since leaving Valencia in 2011.
Approaching the final two months of his United contract, Mata is eligible to talk with overseas clubs and potentially sign a pre-contract agreement to secure his next move.
A report from L'Equipe in France also notes that Bailly has emerged as a target for Lyon
Lukaku, whose 42 goals in a United shirt haven't been enough to justify the vast £90m deal that secured his arrival from Everton in 2017, has brought unnecessary uncertainty to his United future after publicly speaking about his 'dream' of playing Serie A.
"Playing in Serie A is a dream, it would be really a dream," he told Sky Italia. "I hope to be able to play sooner or later, even if at the moment I am focused on the United"
Juventus have been linked with the Belgian in the past, although these days he would probably be a more suitable target for either the of the Milan clubs.