Hasenhüttl's team won on the road at Brighton in the last round of Premier League games and the Austrian boss will hope that his side's good home form will put them in good stead for the visit of Jurgen Klopp's Reds.
Here's a look at how the Saints could lineup for Friday's clash.
Goalkeepers and Defenders
Angus Gunn (GK) - The 23-year-old has been one of Southampton's standout performers under
Jan Bednarek (CB) - The Polish international has 18 league appearances so far this season and will be tested on Friday by the pace possessed by Klopp's side. He should look at former Southampton defender and current Liverpool man Virgil van Dijk for inspiration on how to deal with the likes of the Reds' attackers.
Maya Yoshida (CB) - Yoshida will provide the experience in what is a rather youthful back line, and he could be crucial if Southampton are to keep a clean sheet against the in-form Reds.
Ryan Bertrand (LB) - The 29-year-old has a wealth of experience at Premier League and international level and will have to draw on this to help guide his team to an unlikely victory on Friday.
Pierre-Emile Højbjerg (CDM) - The Danish midfielder is only 23 years old but was made club captain by
Oriol Romeu (CDM) - Romeu has made 21 Premier League appearances so far this season as he has become a key member of the Saints' starting 11 since his move to the south coast in 2015.
James Ward-Prowse (CAM) - The Englishman has been superb since being brought back into the fold by
Stuart Armstrong (CAM) - 27-year-old Armstrong has 24 Premier League appearances since his move to Southampton last summer. He has also contributed some goals and will be hoping to net against Liverpool on Friday.
Charlie Austin (ST) - Despite struggling with injury, Austin has managed 20 league appearances this season and in the absence of fellow Englishman Danny Ings, who can't face his parent club, will get a chance to impress