Fulham host Leicester for the first midweek game of December. kicking off the festive period's packed football calendar.
The Cottagers' new manager Claudio Ranieri will look to return to winning ways after starting his Fulham career with a win against Southampton, before slumping to defeat to city rivals Chelsea.
Injuries to Andre Schurrle, Kevin McDonald and Andre-Frank Zambo Anguissa will plague Ranieri's team selection for the upcoming match, and the remaining players will have to be at their top in order to impress.
Here's a look at how Fulham might line up:
3. Goalkeeper & Defenders
Sergio Rico (GK) - Rico will keep his place as Fulham's number after their troublesome start to the season saw them test three different goalkeepers in the League.
Cyrus Christie (RB) - Christie needs to return to form and cement his place after suffering a poor start to the season.
Alfie Mawson (CB) - Mawson hasn't featured much this season under old manager Slavisa Jokanovic, but will be desperate to impress Ranieri.
Denis Odoi (CB) - Odoi is a ball-playing centre back and enjoys finding passes from deep. He needs to find his confidence after it has been missing at times this season.
Maxime Le Marchand (LB) - Le Marchand has been played in several positions this season, but will get the nod at left-back and will look to nail it down as his preferred position.
Calum Chambers (CDM) - Chambers will likely occupy a holding midfielder role with the absence of Anguissa. He has shown glimpses of his ability in the role but needs a solid performance.
Jean Michael Seri (CDM) - Seri will occupy a deeper role alongside Chambers, and will enjoy having a more defensive orientated partner as he will look to get forward more.
Stefan Johansen (RM) - Johansen will start on the right and offer a wide option with his neat passing. He also has good set-piece delivery.
Tom Cairney (CAM) - Captain Cairney will lead his side by example as the creative link in midfield. He will be at the centre of all of Fulham's attacking play.
Ryan Sessegnon (LM) - The youngster will occupy a more attacking role than earlier in the season. He will look to get forward to support lone striker Aleksandar Mitrovic.
Aleksandar Mitrovic (ST) - Mitrovic will be the key man for Fulham on Wednesday. He will hold up the ball to bring his midfielders into play, and cause problems both aerially and on the ground.
Having scored a brace two weeks ago, Mitrovic is now tied third on the top-scorers charts despite Fulham being bottom of the table.