Bournemouth face a tough away day at the Etihad as they bid to turn their losing run around. City have won all six games the two sides have played in the Premier League, triumphing 4-0 the last time the sides met last season.
City will want to return to winning ways after their tough away draw at Lyon in the Champions League. However, they are stretched quite thin in midfield with a few key injuries.
Here are four key battles which could help decide which team will come out on top.
4. Sergio Aguero vs Nathan Ake
Centre back Nathan Ake will have the job of defending against in form Argentina forward Sergio Aguero. Aguero has been electric this season, with eight goals and four assists already this Premier League campaign.
He will come up against Bournemouth's centre back pairing of Nathan Ake and Steve Cook who offer both pace and physicality. The Argentine will feed off his wingers' supply, so Ake will have to be alert to any dangerous passes and crosses coming into Aguero, closing down the striker's space very quickly.
3. Callum Wilson vs Ederson
Callum Wilson is in the form of his life this season. He has scored six goals, has four assists to his name in the Premier League and recently scored for England on his debut.
Wilson possess the pace to get in behind City's defence. If City occupy a high pressed line which they often do, there will be space in behind for Wilson to run into.
Ederson will have to be wary of this space and keep communicating with his defenders, but if it comes down to it, Ederson may have a few stops to make.
2. Ryan Fraser vs Kyle Walker
Ryan Fraser is quick, but his pace is equally matched by Manchester City right back Kyle Walker. Fraser has been in good form this season as one of Bournemouth's attacking sparks, running channels down the left flank and using his quick feet and skill.
Given the chance he will test Walker one on one and attempt to create chances for himself or his teammates. Walker will need to stay alert and not get caught out of position, because Fraser is not an easy man to stop when he is running at full speed.
1. David Silva vs Lewis Cook
Bournemouth's Jefferson Lerma, who is missing through suspension, is a big loss. He has been a physical presence as a holding midfielder as he anchors the remaining midfielders, cutting out the space between the lines.
David Silva loves to occupy the space between defence and midfield and when he isn't closed down properly he creates fantastic opportunities going forwards.
Lewis Cook will have to stick to his man very tightly in a more unorthodox role for him. If he doesn't, Silva will have the space he needs to unlock Bournemouth's defence with ease.