After a disappointing Champions League defeat at the hands of Atletico Madrid, Die Schwarzgelben will be looking to bounce back and preserve their unbeaten Bundesliga record, which currently stands at 10 games.
However, Saturday’s Klassiker will be Lucien Favre’s biggest test so far since taking charge and will be one that he won't want to lose. Here’s a look at the best potential side Favre can put out for BVB's biggest domestic game of the season so far.
1. Goalkeeper and Defenders
Roman Bürki (GK) – The Swiss goalkeeper has firmly established himself as the number one at Signal Iduna Park, with 15 appearances this season. He has kept an impressive seven clean sheets, which he will hope to make eight on Saturday.
Lukas Piszczek (RB) – Following a short time on the sidelines, Piszczek returned in Wednesday’s defeat and will likely play once more on Saturday. His experience will be key against Bayern, in a slightly inexperienced defence.
Manuel Akanji (CB) – After returning from a brief injury, Akanji has slotted straight back into the Dortmund defence. The Swiss has been a regular this season, and he will be hoping to put in another strong performance against Bayern.
Dan-Axel Zagadou (CB) – With Abdou Diallo a doubt for Saturday’s game, Dan-Axel Zagadou is expected to fill in alongside Akanji in central defence.
Achraf Hakimi (LB) – Although usually a right-back, Hakimi will likely fill in on the left with the return of Piszczek. The Moroccan has been outstanding this season, putting in great performances since moving on loan from Real Madrid.
Axel Witsel (DM) – The heart of an excellent Dortmund side, Witsel will be pivotal if Die Schwarzgelben are to beat Bayern. He has been outstanding since joining in the summer and will be keen to prove his worth in the biggest fixture of the season so far.
Thomas Delaney (DM) – Delaney has formed a superb partnership with Witsel in central midfield since joining from Werder Bremen in the summer. The Dane will face a tough challenge against the likes of James Rodriguez and Leon Goretzka, but he'll be more than up for the fight.
Marco Reus (AM) – The captain will hope to guide his team to a famous win, with memories of BVB's 6-0 hammering in this fixture in March still fresh in the memory. Reus will be the spearhead of many of Dortmund’s attacks, as he has been all season.
Jadon Sancho (RW) – The English youngster is lighting up the Bundesliga with outstanding cameo performances, and it could be time to see what he's got in his locker from the start. Sancho has registered four goals and six assists this season - more than any other player in the Bundesliga.
Paco Alcacer (ST) – Alcacer has been on fire this season, scoring a remarkable eight goals in seven games. He has found the back of the net in all but one of his league appearances, and will be hoping to add to his tally against Bayern's sturdy defence.
Jacob Bruun Larsen (LW) – This is Lucien Favre’s toughest decision for Saturday, with Christian Pulisic and Jacob Bruun Larsen both deserving of starting berths. However, it seems that the latter will get the nod, having featured in Dortmund’s last six league games. Could be a key player.