Southampton host Newcastle this weekend in desperate need of a win to move them away from the bottom three.
It already looks like it will be another tough campaign for the Saints, who are winless in five and haven't scored in their last four. With an entirely clean bill of health, they have room for rotation, but Hughes seems unlikely to make wholesale changes as he hopes for a reversal of fortunes.
This is the lineup Southampton could field on Saturday.
1. Goalkeeper & Defenders
Alex McCarthy (GK) - The 28-year-old is yet to miss a minute of Premier League football this season, but needs more protection from his defence.
Cedric Soares (RB) - The Portuguese full back has started every match for the Saints in this campaign. He'll face a tough examination from Newcastle winger Kenedy.
Jack Stephens (CB) - Stephens made his first start since August against Bournemouth and deserves another chance after keeping a clean sheet.
Wesley Hoedt (CB) - An ever-present at the heart of Southampton's defence, Hoedt's most memorable moment of the season so far was his bizarre own goal against Liverpool.
Ryan Bertrand (LB) - Another who is yet to miss a minute of action this season, Bertrand has captained Southampton in the absence of Steven Davis this season, as he did in the second half of 2017/18.
Mohamed Elyounoussi (RM) - Southampton might have expected more from Elyounoussi, who was a devilishly tricky winger at Basel but is yet to register an assist for his new team.
Pierre-Emile Hojbjerg (CM) - Hojbjerg didn't score once in his debut Premier League season but already has two far this season, including a belter against Brighton. His midfield battle with Jonjo Shelvey should be one to watch.
Mario Lemina (CM) - Lemina was replaced by Stuart Armstrong in the 66th minute at Bournemouth, but Mark Hughes has confirmed that it was only a minor case of hyperextension. The Gabonese international should be fit to start.
Nathan Redmond (LM) - Redmond is fast approaching a century of appearances for Southampton but with only nine goals and seven assists in that time - and none this season - the jury is still out.
Charlie Austin (ST) - It's now 13 games since Austin scored a Premier League goal, the longest barren run he has ever encountered in the top flight. With Manolo Gabbiadini providing competition for places, he needs to get back among the goals.
Danny Ings (ST) - Having scored in three of his first four starts for Southampton, the onus is on Ings to break Southampton's six hour goal drought and lead them to a much needed three points.