Recent headlines have been dominated by the ongoing issues between Mourinho and Paul Pogba, creating an incredibly negative mood around Old Trafford. Results on the pitch have also frustrated fans, as the club find themselves in eighth place in the league.
It seemed certain that Mourinho would be relieved of his duties at the club as they fell two goals behind against Newcastle United in their last match, but the players showed heart and passion as they fought back to win 3-2. They will certainly need more of the same if they are to earn a result against Chelsea.
Here's how they could line up.
1. Goalkeeper & Defenders
Antonio Valencia (RB) - Valencia's contract has been widely discussed recently, with reports suggesting he will be leaving the club for free in the near future. However, he is one of the side's most reliable options on the field, and will be hoping that Mourinho is willing to restore him to the team on Saturday.
Chris Smalling (CB) - Smalling has enjoyed a fantastic few months in the heart of United's defence, with many fans suggesting that his new haircut is the reason for his impressive form.
Eric Bailly (CB) - Unfortunately, Smalling is the only centre back who seems to be impressing for United. Bailly and Lindelof have both failed to perform well, but Mourinho will be forced to choose between them on Saturday, with Bailly likely to be given the nod.
Luke Shaw (LB) - Shaw has signed a new £195,000-a-week contract at the club, meaning he will likely be the team's preferred left back for years to come.
Nemanja Matic (CM) - The towering Serbian has been suffering with an injury during the international break, but Mourinho will be relying on Matic's defensive stability to neutralise Chelsea's midfield.
Fred (CM) - Mourinho has previously asked Ander Herrera to focus completely on disrupting Eden Hazard but, with the Spaniard struggling for fitness, expect the tenacious Fred to take his place.
Paul Pogba (CM) - He may not be the side's vice-captain anymore, but Pogba is still arguably his side's most important player. He will come up against the destructive force that is N'Golo Kante, meaning Pogba will need to be at his best to impact this game.
Marcus Rashford (LW) - Rashford struggled greatly during the international break, but will likely be given the chance to show his improvement on Saturday.
Romelu Lukaku (ST) - It will be a return to Stamford Bridge for the former Chelsea striker, and Lukaku will be eager to prove to the club that they made a mistake in selling him.
Alexis Sanchez (RW) - Sanchez is good enough to make a serious impact on this match, but we simply have not seen the best of him in Manchester. Fans will be hoping that he will finally show his true talent on Saturday.