Unfortunately, life in the red half of Manchester has not been so positive this year. Jose Mourinho's job security has stolen the headlines in recent weeks, but performances on the pitch have frustrated fans as United find themselves in eighth place in the league.
The clash between the two certainly has the potential to be one of the top matches of the season, and here's a combined XI of players from the two rivals.
1. David de Gea
De Gea is widely regarded as one of the top goalkeepers in the world, and rightly so. The Spaniard has produced some phenomenal saves in between the posts for United, and has won his side countless points.
He makes our combined XI ahead of Chelsea's Kepa, who is also behind the United man in the Spain national team.
Kepa may well be the world's most expensive goalkeeper, but he has a long way to go before he can reach the same level as de Gea.
2. Cesar Azpilicueta
The second Spaniard in the side, Azpilicueta has earned a reputation as one of the Premier League's finest defenders.
The man known as 'Dave' offers Chelsea some undying commitment and leadership, and is arguably the best one-on-one defender in England. His defensive knowledge is incredibly impressive, whilst he also has the capabilities to make an impact at the other end of the field.
He managed an impressive six assists in the league last season, which is a fantastic tally given the 29-year-old was playing as a centre back. Azpilicueta's crosses give the team an extra edge in attack, and he has earned his reputation as a top right back.
3. Chris Smalling
It seemed as though Chris Smalling's time in Manchester might have been coming to an end, but the 28-year-old has been proving that he deserves his place in United's starting XI this season.
He has arguably been his side's best defender this season, with both Eric Bailly and Victor Lindelof failing to impress. Many fans have been suggesting that his impressive form is down to the defender's new hair cut, but Smalling deserves the credit for proving his doubters wrong.
Smalling is one of several United players who have entered the final year of their contracts, and the club would be crazy to let Smalling walk away for free in the summer.
4. Antonio Rudiger
The towering German has become a fan favourite at Chelsea, with his no-nonsense attitude to defending winning him countless plaudits since his arrival in London.
The 25-year-old has also impressed with the ball at his feet, helping to kick start countless Chelsea attacks, whilst also offering serious defensive stability to his team. Chelsea's attackers are happy to commit in the final third of the field, knowing Rudiger is behind them to protect Kepa.
Rudiger has been a key player for Chelsea under Sarri, featuring in every league game this season. He will be desperate to recover from his injury in time to help his side against the Red Devils.
5. Luke Shaw
Like Smalling, many believed that Shaw's time at United would soon be coming to an end, after the 23-year-old has struggled with injuries and form during his four years at the club. However, Shaw has started this season in immense form, earning a long-awaited return to the England setup in September.
Physically, Shaw looks impressive. He loves to run at defenders, using his speed and power to beat his man before whipping a dangerous cross into the box. He is equally as impressive in defence, and deserves his place at United once more.
During his eight Premier League appearances to date, Jorginho has transformed the way that several fans view the game of football. He is a phenomenal passer of the ball, and is a major reason why 'Sarriball' have been so effective all over Europe.
He was wanted by many of Europe's elite this summer, but chose to follow Sarri to London to continue his development under the Italian. His love of passing helps his team move forward down the pitch and constantly forces defenders out of position to try defend their attack.
Jorginho is the heart of Chelsea's team, and looks to be a fantastic buy for the club.
7. N'Golo Kante
France's World Cup victory has certainly cemented Kante's place as one of the finest central midfielders in the world, with his ability to read and respond to danger second to none.
Since arriving at Chelsea, Kante has improved with each passing year. He is now a complete midfielder, capable of passing or running with the ball, whilst also offering an obscene level of defensive cover for his teammates.
His inclusion on the 30-man shortlist for the Ballon d'Or is certainly deserved, but the humble Frenchman is more concerned with the success of his teammates, which makes Kante a valuable commodity for Chelsea.
8. Paul Pogba
On his day, Paul Pogba is one of the best players in the world. He has the ability to drift past defenders with ease, whilst his passing and shooting skills make him a dangerous threat from almost any area of the field.
Questions have been asked about Pogba's attitude this season, but his talent on the football pitch is undeniable.
He will certainly have a huge part to play in the outcome of Saturday's match, and will certainly relish being the creative focal point of his side.
Even though he may struggle with consistency, Willian has proven to be a serious threat for his team on the right side of their attack. The Brazilian loves to run at defenders, using his pace and footwork to dazzle countless defenders.
Under Sarri, Willian has the potential to greatly improve his goal tally, and resisting Barcelona's advances this summer could prove to be a smart decision for Chelsea as this season progresses.
10. Romelu Lukaku
Lukaku's inclusion on this lineup is one of the more straightforward decisions. Alvaro Morata's Chelsea career has turned shambolic, whilst the popular Olivier Giroud struggles just as much to find the back of the net.
Lukaku averages one goal every two matches for United, and Chelsea fans would love a striker with a similar goal record.
With four goals to his name already this season, Lukaku will be desperate to perform against his former club on Saturday.
11. Eden Hazard
Hazard has looked simply phenomenal this season. The Premier League has never seen the Belgian play so well, and his seven goals this season have seen Hazard's name mentioned in the never-ending 'best player in the world' debate.
He is clearly enjoying working with Maurizio Sarri, who has liberated Hazard and allowed him to play with a level of creative freedom which simply terrifies opposition defenders.
Chelsea fans are desperate for Hazard to resist the urge to join Real Madrid, and it is not hard to see why.