Wolves boss Nuno Espirito Santo has got off to a great start this season, last time out against Southampton they ran out 2-0 winners, Santo will be hoping for the same dominant performance this weekend.
Here are four key battles that could very well decide the tie.
1. Wilfried Zaha vs. Conor Coady
The Eagles talisman Wilfried Zaha has had a great start to the season, continuing on from his form last season, he comes up against Conor Coady this weekend.
Coady has proved himself to be a solid and commanding operator in the middle of the back three for Wolves this season.
Zaha's flair and speed could prove difficult to handle as the Ivory Coast international likes roaming into central positions, and Coady will need to be on top form to stop him
2. Joao Moutinho vs. Luka Milivojevic
Joao Moutinho is a highly experienced central midfielder but he'll have to be on top form to win the midfield battle against Luka Milivojevic.
Wolves' start has been testament to solidarity all over the pitch, and effectively utilising the experience of Moutinho to connect defence and attack. Without Moutinho's influence Wolves may have struggled to dominate games like they have so far this season.
Milivojevic has been at the centre of the Eagles midfield for the best part of three seasons and will have to use his calm head to make the right decision when up against Moutinho.
3. Raul Jimenez vs. Mamadou Sakho
Raul Jimenez has started every game this season under Santo, and faces the tough task of getting past Mamadou Sakho this weekend.
Since his loan move from Benfica, Jimenez has proved he is a reliable asset for Wolves, scoring two goals so far this season.
Sakho has also started the season on good form and seems to be enjoying life under Roy Hodgson, after earning a recall to the French national team he'll have to be wary of Jimenez's threat.
4. Patrick van Aanholt vs. Helder Costa
Patrick van Aanholt thrives when he's in attacking areas from his left back position but the threat of Helder Costa may mean the defender has to be more reserved this weekend.
The Dutch international has been impressive in both a defensive and attacking sense this season with one assist and one goal to his name.
Costa has continued to perform after his sensational season when Wolves got promoted, his performances have been impressive, van Aanholt will have to be wary of the danger Costa poses.