Tottenham will be looking to bounce back after their midweek lost to Barcelona in the Champions League; a game where Messi's individual brilliance was ultimately the difference between the two sides. Fortunately, Cardiff don't quite have a player of Lionel Messi's calibre.
With a spate of injuries across the squad, and that massive midweek fixture behind them, Mauricio Pochettino has a lot to consider when picking his side this weekend.
Here's a look at how they could line up.
1. Goalkeeper & Defenders
Hugo Lloris (GK) - Lloris hasn't played in the league since the 3-0 win over Manchester United back at the end of August. But he returned last night in dramatic fashion against Barcelona. It was his mistake early on which lead to Philippe Coutinho's opener, but it's unlikely that one mistake will see Pochettino lose faith with the World Cup winner so suddenly.
Kieran Trippier (RB) - The English World Cup hero suffered against Messi's Barcelona on Wednesday. However, he's a key player in this Tottenham side, and he'll be needed to help get them back to winning ways.
Toby Alderweireld (CB) - Now truly back in the team, and without the injured Jan Vertonghen, Alderweireld will most likely get the nod on Saturday.
Davidson Sanchez (CB) - With that hamstring injury to Vertonghen, there aren't many options in the centre back department. Sanchez started midweek and he'll probably partner Alderweireld once more.
Danny Rose (LB) - He's started the last three league matches, and after Ben Davies got the nod against Barcelona, expect Rose to return to the fold.
Eric Dier (DM) - Mousa Dembélé is a big miss in the middle of the park, but the Englishman will hope to plug the gaps after being omitted from the starting line-up midweek.
Victor Wanyama (DM) - He's struggled to get minutes in the league so far, but Pochettino might prefer Wanyama's brawn to Harry Winks' guile.
Erik Lamela (RAM) - He scored against Liverpool, he scored against Brighton, and then he scored against Barcelona. Put simply, Lamela has to start.
Heung-Min son (LAM) - Interchanging in the attacking roles with Lamela and Lucas, Son will hope to do some real damage against a leaky Cardiff backline.
Harry Kane (ST) - The best number nine in world football? Definitely.
Lucas Moura (ST) - Although he arrived last January, Lucas has been like a new signing for Spurs this season - which is a bit of luck, in the absence of any actual new signings. He'll add pace and trickery playing in the second striker role, hovering off and around Harry Kane's shoulder.