A tight first half at Old Trafford saw the two Premier League powerhouses go in goalless at the break.
However, brilliant goals from Harry Kane and Lucas Moura gave Spurs a dream start to the second half with both goals coming within the first seven minutes of the restart. A third added once again by Moura saw off Mourinho's side for good, as
Check out the talking points of the game below.
Key Talking Point
Mourinho will not want to look back on tonight anytime soon, as his side failed miserably to make up for last week's loss to Brighton.
A below par start to the second half, saw United two down within seven minutes. There was no reaction from a poor Red Devils side which left the fans in anger, with many choosing to leave the match early.
The Portuguese boss, who suffered the biggest home loss of his career, took a moment to salute the fans before walking down the tunnel at full-time - a move some have taken as a sign of his possible imminent departure.
WATCH: Really bizarre moment here at Old Trafford. Jose Mourinho applauds Stretford End for nearly a minute after Manchester United were hammered 3-0 by Tottenham. He’s thrown a scarf and then looks close to tears. #MUFC #MUNTOT #THFC pic.twitter.com/0AcNnjGxgl— Joe Prince-Wright (@JPW_NBCSports) August 27, 2018
Man united have conceded SIX goals in 2 games. Jose Mourinho just stood and clapped in front of the Old Trafford crowd for a rather long time. What on earth is coming next.. #MUNTOT— Jules Breach (@julesbreach) August 27, 2018
Seems to me, Mourinho’s reaction to the crowd there tells me he knows it’s over.— Scott Saunders (@_scottsaunders) August 27, 2018
Would not shock me if he walked.
Starting XI: De Gea (5), Valencia (4), Jones (3), Smalling (4), Shaw (5), Matic (5), Herrera (4), Fred (4), Pogba (4), Lingard (5), Lukaku (3)
Substitutes: Lindelof (4), Sanchez (5), Fellaini (5)
STAR MAN - United's Faithful would have been glad to see the return of World Cup hero Jesse Lingard.
The England International was energetic, as he looked to break between the lines and create opportunities for his teammates. Although missing a key chance in the second half which was deflected over the bar, Lingard tried his best to make things happen for a stubborn United side.
Lingard has been our best player 狼— Hamza Shakoor (@HamzaShakoor699) August 27, 2018
WORST PLAYER - Mourinho needed his star players to perform for him this evening, with Romelu Lukaku letting his boss down.
A first half open goal miss was the highlight of the Belgian's night, as a number off misplaced touches added to the strikers frustrations.
Lukaku scores that first half chance, it's a completely different game— #GBEVU BOY (@pk_YNWA) August 27, 2018
#mufc were decent in the first-half but as soon as Spurs were remotely clinical it went to pot. The defence is a mess, Pogba was shambolic and Lukaku costly again. Boos at full-time.— Samuel Luckhurst (@samuelluckhurst) August 27, 2018
Can Lukaku actually control the ball and lay off a pass pls— James West (@J_West96) August 27, 2018
Key Talking Point
Prior to kick-off
Starting XI: Lloris (7), Trippier (7), Alderweireld (6), Vertonghen (7), Rose (6), Dier (6), Dembele (7), Eriksen (7), Moura (9), Alli (7), Kane (8)
Substitutes: Aurier (6), Davies (6), Winks (6)
STAR MAN - Scoring a double away at Old Trafford is a rare accomplishment, but Lucas Moura joined an exclusive club with special individual performance.
The Brazilian put in a great display in front of the Spurs fans who would have been worried they hadn't replaced South Korean winger
I’ve been very impressed by Lucas Moura today. He’s been my MOTM— ً (@BabyKeith8) August 27, 2018
Next time I hit barbers I’m getting the Lucas Moura trim. Legendary— A (@26Ameerr) August 27, 2018
WORST PLAYER- The man that struggled against United this evening was returning full-back Danny Rose.
Rose, saw himself taken off in the second half with the worry of yet another injury to the England defender. A first half misplaced pass gifted Lukaku a dream opportunity to take the lead, which, luckily for Rose, he missed.
Mourinho's side will look to bounce back from consecutive defeats as the Red Devils travel to Turf Moor to play Burnley next Sunday.
Spurs will be looking to keep up their 100% record at the start of the season as they take on high flyers Watford at Vicarage Road.