The two heavyweights renew their immense rivalry, which has thrown up some titanic battles over the years, as the two clubs shared every Premier League title bar one between 2005 and 2013.
Here are eight classic clashes between the two rivals:
8. Man Utd 4-0 Chelsea (1994 FA Cup Final)
The two sides have met in two previous finals, with both sides prevailing once. United came out on top in 1994, with the league champions completing the double by trouncing a game Blues side.
Glenn Hoddle's Chelsea had been on top for much of the first half but failed to find the breakthrough, before United turned the game on its head. A frenetic nine minute spell took the game away from the west Londoners, with two Eric Cantona penalties either side of a well-taken Mark Hughes goal putting Sir Alex's men into a commanding lead.
Brian McClair added a fourth late on to compound Chelsea's misery and seal a comfortable victory for the Red Devils.
7. Chelsea 5-0 Manchester United (1998-99)
Perhaps the arrival of Chelsea as a perennial challenger for the European spots, Chelsea ended an eight month unbeaten run by the visitors to maul the then-champions 5-0.
Gus Poyet opened the scoring after only 28 seconds due to a Massimo Taibi howler in the United goal. Chris Sutton doubled the lead 15 minutes later with a smart header, before United were reduced to ten men when Nicky Butt was sent off midway through the first half.
It became conclusive after half time, with two strikes in two minutes from Poyet and a Henning Berg own goal ending the game as a contest, with Jody Morris making it five in the dying minutes for a famous victory.
6. Chelsea 1-0 Manchester United (2004-05)
Whilst a fairly innocuous game on first glance, it holds the distinction of being Jose Mourinho's first game in English football, with the fixture list throwing up a clash against Sir Alex Ferguson on the opening day.
Fresh off winning the Champions League with Porto, Mourinho made a fast start to life at Stamford Bridge, with Eidur Gudjohnsen's goal after 14 minutes enough to see off the challenge of the Red Devils.
Late chances from Ryan Giggs were unsuccessful and the home side held on for an opening three points, never to look back, with the Portuguese's maiden campaign ending in Chelsea's first league title for 50 years.
5. Chelsea 3-0 Manchester United (2005-06)
United returned to Stamford Bridge the following season in April 2006, where Chelsea needed only a point to secure back-to-back titles for Jose Mourinho.
William Gallas gave the home side the perfect start after five minutes, nodding in from a corner. The visitors threatened, before Joe Cole gave Chelsea a cushion with a sensational individual goal on the hour mark.
The Englishman made his way through three United defenders before thumping the ball into the roof of Edwin van der Sar's net, to mass celebrations in west London. Defender Ricardo Carvalho ran the length of the pitch to score a late third and compound the Manchester club's misery, establishing Chelsea as the team to beat.
4. Manchester United 1-1 Chelsea (2008 Champions League Final)
Ask any Chelsea fan the most painful moment of the last 20 years, and they will tell you of a rainy night in Moscow in 2008.
With United having pipped Chelsea to the Premier League title on the final day, Avram Grant's men were looking to secure a maiden Champions League and deliver the holy grail for Roman Abramovich in his home country.
Cristiano Ronaldo scored the 42nd goal of a remarkable season to give Sir Alex's men the lead, before Frank Lampard snuck in on the stroke of half time to level for the Blues. Chelsea had the better of the second half, with Lampard and Didier Drogba striking the woodwork before extra time.
It was the Ivorian who turned the game on its head, with a petulant wave of the hand towards Nemanja Matic earning Drogba an early bath midway through the extra period. In the penalty shootout, Ronaldo missed, with all Chelsea players converting, leaving it to captain John Terry to win the Champions League. In what would've been Didier Drogba's spot as the fifth penalty, Terry slipped and hit the post, and was left inconsolable.
Ryan Giggs converted and Nicolas Anelka's penalty was saved by van der Sar to give United a domestic and European double and cement them as best team on the continent.
3. Chelsea 3-3 Manchester United (2011-12)
A modern Premier League classic unfolded in February 2012, with Chelsea throwing away a three goal lead with half an hour to play to only earn a point.
The Blues had blown away their visitors either side of half time, with a Jonny Evans own goal opening the scoring nine minutes before the interval. Juan Mata's special volley and a David Luiz header four minutes later appeared to have continued United's wretched record at Stamford Bridge, with a convincing victory on the cards.
Two well taken penalties from Wayne Rooney reduced the deficit before Javier Hernandez popped up six minutes from time to head past Petr Cech and secure an unlikely point, celebrated like a victory amongst the United fans.
2. Chelsea 2-3 Manchester United (2012-13)
An ill-tempered game saw only the second Manchester United win at Stamford Bridge since the turn of the century, with another late Javier Hernandez goal enough to down nine-man Chelsea.
A David Luiz own goal and Robin van Persie finish gave the visitors a commanding two goal cushion inside a quarter of an hour, before goals either side of half time from Juan Mata and Ramires levelled the scores for the Blues.
Two controversial red cards from Mark Clattenburg after the hour mark turned the game on its head, with Branislav Ivanovic first shown red for a late challenge and then Fernando Torres for diving six minutes later, with Roberto di Matteo incensed in the Chelsea dugout.
Forced to sit back, it set the stage for a late United winner, with old adversary Hernandez turning in 15 minutes from time to give Sir Alex Ferguson's men a priceless victory, with United going on to romp to the title in the Scotsman's last season at Old Trafford.
1. Chelsea 4-0 Manchester United (2016-17)
The first meeting between Antonio Conte and Jose Mourinho was highly anticipated, with Mourinho sacked by Chelsea less than a year previous, and now finding himself in the Old Trafford hotseat.
His first return to Stamford Bridge was a miserable one, with Conte's 3-4-3 system playing United off the park and ensuring a drubbing for the ex-Chelsea boss.
Pedro opened the scoring after 30 seconds following a mistake from David de Gea, and Gary Cahill turned in from a corner 20 minutes later to double the Blues' lead. After the break, Chelsea never looked like letting up, with Eden Hazard adding a third and N'Golo Kante weaving around the United defence to score a memorable first goal for the club, compounding the visitors' misery.