With a place in the Champions League to secure, Spurs will be desperate to pick up all three points to keep themselves in the driving seat as they battle Liverpool and Chelsea for the final two spots in the top four.
With so much at stake, Mauricio Pochettino is expected to pick his best XI available. And with that in mind, here is how the Spurs boss could set his team up...
The French keeper is Tottenham's number one, and Lloris will keep his place between the sticks.
Despite rotating between Kieran Trippier and Serge Aurier for the majority of the campaign, Pochettino has opted to play the Englishman on the right flank for the past three fixtures, and the favoured right back can be expected to start again on Wednesday night.
Sanchez will keep his usual place in the starting XI, while Toby Alderweireld, who was handed his first league start since October at the weekend, is likely to keep his place, with Jan Vertonghen an injury doubt.
Ben Davies is expected to return to the starting lineup, with fellow left back Danny Rose having played the game at the weekend.
Eric Dier is expected to start after a rare omission from the starting XI against West Brom on Saturday. And Victor Wanyama is likely to keep his place, as a result of Mousa Dembele being an injury doubt for the Lilywhites, with Pochettino likely to revert back to a 4-2-3-1 formation.
The Argentine manager opted to start Erik Lamela at the weekend, but Heung-Min Son can be expected to return to the starting lineup for this midweek fixture. Whilst Christian Eriksen and Dele Alli are almost certain to start alongside the South Korean, forming their usual three behind Harry Kane.
Despite currently struggling to find his usual form in front of goal, it would be a huge shock if Kane did not start for Spurs. The England striker, who bagged seven goals in the final week of the season last term, is expected to lead the line on Wednesday night.