Arsenal boss Arsène Wenger has one last shot at European glory with the Gunners, after confirming that he will be leaving the club at the end of the season.
The aggregate score is currently 1-1 as Arsenal travel to Atlético Madrid's Wanda Metropolitano Stadium for the second leg on Thursday.
This match will be Wenger's 250th European game in charge of the Gunners and his side will be favourites to win the final in Lyon should they progress on Thursday night.
Arsenal and Atlético never played each other until the first leg, only ever meeting in a pre-season Emirates Cup game that finished 2-1 to Arsenal back in 2009.
The first leg took place just last week and the aggregate score is currently 1-1 thanks to goals from French strikers Alexandre Lacazette and Antoine Griezmann.
Atlético were at a disadvantage from early on, when defender Šime
Diego Costa vs Laurent Koscielny
Diego Costa will be looking to rediscover his form after a less than impressive performance in Atlético's 1-0 victory over Alves last weekend.
The former Chelsea striker was playing his first game in three weeks and will now be looking to rekindle his partnership with French striker Antoine Griezmann.
Costa will be a familiar opponent for the Arsenal defence but, likewise, the Arsenal defence will be familiar to Costa. This will make for an interesting battle at the back and whoever gets on top of this will give their side control of the tie.
Ángel Correa vs Héctor Bellerín
3 puntos muy importantes para seguir sumando 💪⚽️ pic.twitter.com/kza4PhgP8q— Angel Correa (@AngelCorrea32) April 15, 2018
Atlético's 23-year-old winger Ángel Correa will be in for a tough evening as he comes up against one of Europe's most talented right backs in Héctor Bellerín.
However, if Arsenal are disorganised when Bellerín attacks high up the pitch, they could present opportunities for Correa to exploit the space left behind and cause problems for the Arsenal defence.
Correa is not known for scoring goals, however he is a joy to watch with the ball at his feet and can create opportunities out of nothing. A serious threat to the Arsenal side.
Atlético Madrid will be without right back
Meanwhile, David Ospina is set to start for Arsenal as he continues to feature in cup competitions under Wenger.
Henrikh Mkhitaryan is also expected to continue his comeback from injury after playing and scoring against Manchester Untied at the weekend.
Atlético Madrid predicted lineup: Oblak; Gimenez, Godin, Savic, Hernandez; Koke, Gabi, Saul Niguez, Correa; Costa, Griezmann.
Arsenal predicted lineup: Ospina; Bellerin, Mustafi, Koscielny, Monreal; Xhaka, Wilshere, Ramsey; Ozil, Mkhitaryan; Lacazette.
It will be hard to see a full-strength Atlético Madrid side conceding goals at the Wanda Metropolitano stadium.
Despite Arsenal's desire to earn European glory in Wenger's final season, Diego Simeone's side may just have too much for the Gunners on this occasion.
Antoine Griezmann and Diego Costa are capable of striking an unstoppable partnership. In fact, Atlético's team is built on a string of successful partnerships across the park in their rigid 4-4-2 formation.
Prediction: Atlético Madrid 1-0 Arsenal (2-1 on aggregate)