The England striker had one his quietest ever games in a Spurs shirt at Wembley, although he did have a hand in Christian Eriksen's goal.
The 24-year-old look extremely isolated at times as City dominated the ball, and had no meaningful chances in the game as the visitors took all three points.
The defeat by the champions elect wasn't too damaging in that Spurs are still a healthy seven points ahead of Chelsea in the race for the final Champions League spot.
It was still a concerning performance though, with the gulf between the two sides evidently larger than what Mauricio Pochettino would have thought.
Oddly no-one seemed to mention that Kane was completely anonymous, Harry just didn’t look at the races today, couldn’t ever get into the game at all, all we can hope is that 90mins tonight means he’s rating for next Saturday because we will need him at his best— Ben Boorman (@benspurs21) 14 April 2018
Harry Kane isn’t fit is he— Charlie Oakman (@CharlieOakman_) 14 April 2018
Kane clearly isn’t fit— Steve Vicarage (@svic83THFC) 15 April 2018
Harry Kane on the other hand does NOT look fit. Clearly has rushed himself back from injury and it was evident today if not already at Stoke last week. Needs to regain his form soon. In 7 days, we play our biggest game of the season. #THFC #COYS— Ali (@AliMohddShahid) 14 April 2018
And Harry Kane is not fit at all. Thats not Harry Kane. He has defo rushed back. #THFC— Trevor Lloyd (@Trevorlloyd92) 14 April 2018
Spurs needed somebody to step up and make something happen. Eriksen was lively in spells but Kane was virtually anonymous and when the ball did come to him he was easily contained by Vincent Kompany or Aymeric Laporte.
Judging by Twitter after the game, the Spurs fans certainle expected more of an impact from their talismanic striker.
The opportunity was there for Kane to add to his tally of 25 Premier League goals and catch Mohamed Salah in the race for the Golden Boot, and in turn get people talking about an actual goal he scored rather than his embarrassingly successful goal claim recently to the Premier League.