Southampton host Chelsea looking for a crucial win to keep their survival hopes alive. With the two sides meeting at Wembley next weekend for a place in the FA Cup final, this is a chance to put down a marker and build momentum for the rest of the season.
With the Saints 18th holding a game in hand, it is now or never for Mark Hughes' men who have only beaten bottom club West Brom in their past 19 league matches.
Here's who the Welshman could pick for the visit of Chelsea:
Alex McCarthy will keep his spot in goal.
After Jack Stephens' red card against Arsenal, the youngster is suspended and begins the first match of a three-game ban here.
Maya Yoshida comes into the team to partner Wesley Hoedt, with the Dutchman having a shot cleared off the line late on in Southampton's efforts to find an equaliser last weekend.
Ex-Chelsea man Ryan Bertrand and Cedric Soares will continue on the flanks.
With Steven Davis nursing a knock, the Northern Irishman is a doubt for Saturday's game and will be assessed. Pierre-Emile Hojbjerg could deputise, with the Dane not setting the world alight since last season's move from Bayern Munich.
Oriol Romeu should start against his former club, with Dusan Tadic and James Ward-Prowse looking to provide attacking threat on the wings
Having scored last weekend, Charlie Austin could be nearing a return to form just when Southampton need him most, with the Englishman spending a lot of time on the sidelines this season.
Goal-shy Manolo Gabbiadini possesses the quality to drag the Saints out of the relegation battle and will be crucial if they are to take anything from Saturday's game.