Andy Carroll's stoppage time goal has lifted the Hammers out of the relegation zone, though they face a tough task travelling to Spurs for their fourth game in ten days.
Here is how David Moyes' men could lineup...
Since coming into the side, Adrian has impressed in goal and is likely to keep on-loan Joe Hart on the bench once more.
David Moyes has implemented three central defenders for the majority of his time at West Ham. He did switch to a back four in the second half of Tuesday's game against West Brom, but lost Aaron Cresswell to injury with fifteen minutes to go.
Declan Rice or James Collins are likely to come in alongside Winston Reid and Angelo Ogbonna in his absence.
Compacting the space and keeping things tight will be the order of the day for the Hammers.
Captain Mark Noble came on at half-time in midweek and his leadership qualities are likely to be called upon for one of the most important fixtures in West Ham's calendar.
David Moyes may look to keep faith with the other midfielders who helped the side defeat the Baggies on Tuesday.
David Moyes has a variety of options to choose from up front, but again may choose selection consistency for this one.
Marko Arnautovic has been the Hammers' main attacking threat in recent weeks, and his presence would be sorely missed if Moyes opted to make a change. Andy Carroll netted twice in midweek, and subject to fitness, will start once more.
Javier Hernandez and Andre Ayew are waiting in the wings if required.