Sam Allardyce will need to change his side up with two games in the space of 48 hours, and has the personnel available to do just that despite a spate of injuries.
Here's how the Toffees may line up on Monday:
If he's fit then he'll start. Jordan Pickford will keep his place in goal.
With no injured full-backs fit enough to return, Jonjoe Kenny and Cuco Martina will have to soldier on at right-back and left-back respectively for the Blues.
Mason Holgate and Ashley Williams will return at centre half to as Allardyce rests veteran defender Phil Jagielka and gives Michael Keane a breather after three successive starts.
James McCarthy may make only his second appearance of the season after a niggling hamstring injury, and would likely start alongside former United stars Morgan Schneiderlin and Wayne Rooney in the heart of midfield.
Yannick Bolasie and Ademola Lookman would be perfect wing additions to give the Blues some much needed pace and trickery on the counter attack too.
If he was rested for the trip to Bournemouth due to the amount of starts he's had then you can expect Dominic Calvert-Lewin to be recalled for the visit of United.
The 20-year-old striker has led the line well under Allardyce and should be raring to go if the 63-year-old opted to give him a breather against the Cherries last Saturday.