Chris Hughton's side will hope to earn a crucial three points to give the Seagulls some breathing space from the sides below them in the relegation zone.
Here's who the manager could select for the crucial relegation six-pointer:
- Ryan 1
Matt Ryan will continue in goal.
Hughton may look to make one change in defence with the games coming thick and fast during the festive period.
Club captain Bruno could come in the replace Ezequiel Schelotto in the only defensive change from the Chelsea game, with Shane Duffy and Lewis Dunk continuing at the heart of the defence and Markus Suttner at left-back.
There may be a couple of changes in midfield after the defeat on Boxing Day, with key duo Anthony Knockaert and Pascal Gross coming in to replace Solly March and Beram Kayal respectively.
Davy Propper and Dale Stephens will continue in the centre of the park, while summer signing Jose Izquierdo will offer pace from the left flank.
The club's top scorer Glenn Murray looks set to replace Tomer Hemed as the lone striker, and will be hoping to add to his five league goals this season.
Murray will be looking to feed off the service that Knockaert and Gross are able to provide.