Sean Dyche's men have been a revelation this season, currently sitting in seventh in the table, three points adrift of the top four.
Although his side suffered a 3-0 loss to Tottenham Hotspur after a hat-trick from Harry Kane, Dyche will hope that his side can shock Old Trafford, as Mourinho's men have looked shaky in past weeks.
An injury to Tom Heaton made way for Nick Pope to start for the Clarets and he has not disappointed since taking over.
The newly appointed Burnley shot-stopper is a big reason for his side boasting nine clean sheets on the season and will look to continue his fine form against United.
Burnley will have to face United without their standout performer James Tarkowski who picked up a three-match ban after being charged with violent conduct. As a result of this, Ben Mee will be partnered up with Kevin Long, who will look to replicate Tarkowski's impressive form.
Phil Bardsley and Charlie Taylor will be the full-backs with the tremendous task of ensuring that United are drained of attacking flair from the wings.
Dyche will look to form a disciplined and unwavering midfield to ensure that the likes of Paul Pogba and Jesse Lingard have no space to operate or cause trouble going forward.
Johann Berg Gudmundsson and Steven Defour will look to control the midfield, which is easier said than done against this United side, while Jack Cork will look to get the ball higher up the pitch, feeding the attackers.
Jeff Hendrick and Chris Wood will look to get in behind the Untied back line and be clinical against one of the world best keepers, David de Gea.
Both Hendrick and Wood were kept quiet by Tottenham in their last fixture and will look to bounce back against a United side who have struggled in recent weeks.