Both Premier League title rivals will be aiming to secure a vital victory but at the same time will be desperate to avoid defeat. Here's all you need to know ahead of Sunday's gigantic clash.
Manchester United 1-6 Manchester City (23/10/11)
Manchester City went into this fixture knowing a win at Old Trafford would give them a five point lead over the Red Devils and a huge boost in their bid to secure a first Premier League title.
The Citizens were 1-0 up at half-time thanks to Mario Balotelli's opener and a Jonny Evans red card. However, Manchester United's second-half capitulation resulted in them conceding a further 5 goals as Balotelli, Sergio Aguero, Edin Dzeko (2) and David Silva all got their names on the scoresheet in the final 45 minutes to secure a famous win for tor the blue half of Manchester.
Darren Fletcher did register a consolation for United when the score was 3-0 but it was not enough to stop City inflicting the Red Devils' largest home defeat in 56 years.
Manchester United's club record signing Paul Pogba will serve the first game of his three-match suspension during the Manchester derby following his red card vs Arsenal last Sunday.
United will also be without Eric Bailly and Michael Carrick, who are both ruled out of the fixture through injury.
David Silva was initially a doubt for the fixture but the Spaniard has now been passed fit to play. Pep Guardiola will be without the defensive duo of John Stones and Benjamin Mendy who are both long term absentees.
Predicted Manchester United lineup:
Predicted Manchester City lineup:
This game is a must win for Jose Mourinho rather than a mustn't lose if Manchester United are going to win the Premier League this season.