Following on from the goalless first leg at the John Smith Stadium, the stage is set for an epic encounter between the two Yorkshire clubs on Wednesday evening at Hillsborough.
There is more than local bragging rights at stake, with both sides vying for a spot in the Championship Playoff Final at Wembley.
Here are three key battles that could prove pivotal in deciding who progresses to the final...
3. Elias Kachunga vs Jack Hunt
The Huddersfield Town top scorer has been pivotal in the rise of David Wagner's side this season, netting 12 league goals. The on-loan forward proved a real threat in the first leg of the tie, giving the Owls endless problems down the right-wing.
Jack Hunt has been a reliable member of a formidable Wednesday defensive unit this season. However, when put under pressure, he is prone to misplacing the odd pass. His level of discipline is also questionable, having collected five yellow cards this season.
Kachunga's pace could rattle Hunt, and any slip-up could be disastrous for Sheffield Wednesday given the importance of the match.
2. Fernando Forestieri vs Christopher Schindler
Fernando Forestieri is an under-rated footballing talent in the eyes of many spectators. The Sheffield Wednesday striker has scored 12 goals this season, and is a constant threat to opposition defenders.
The Argentine is a technically gifted player, capable of dribbling passed the most rigid of defences. Huddersfield Town had little defending to do in the first leg, with the ever-impressive Christopher Schindler stepping in when required to clear the ball to safety.
Schindler has been among Town's best players with season, proving to be an inspired from David Wagner. The battle between the two players will be an intriguing watch, as the skill of Forestieri meets the brute force of Schindler.
1. Aaron Mooy vs Sam Hutchinson
Aaron Mooy has become a cult hero at the John Smith Stadium since joining on loan from Manchester City in the summer. He recently won the clubs player of the season award, and is a master of dictating the game, as well as breaking up play when required.
Sheffield Wednesday are anxiously awaiting the return of Sam Hutchinson from a knee injury. The ex-Chelsea prodigy has had a superb season for the Owls, bringing a raw energy to both the defence and the midfield when required.
Carlos Carvalhal has confirmed that be believes Hutchinson will return for Wednesday's clash. Hutchinson could be just the energy Wednesday need in midfield, and an ideal solution to thwart Mooy's effort to control the game for Huddersfield Town.