Cole had been diagnosed in the summer of 2015 and was unfortunately forced to pull out of participating in David Beckham's UNICEF fundraiser at Old Trafford as a result.
A statement issued by the club on Friday morning read, "During his recuperation, Andrew will be taking a break from his role as Manchester United Ambassador.
"Andrew and his family would like to thank the club and fans for their support. They also request that he can continue with his treatment in private, and ask that their privacy is respected."
Cole became British football's most expensive ever player when he joined United from Newcastle for a fee of £7m in 1995. He'd previously won the Premier League Golden Boot after a thunderous campaign in 1993/94 in which he scored 34 times in 40 league appearances, and later went on to become a five-time Premier League champion.
Cole also twice won the FA Cup, and the Champions League. He is most remembered by fans for his outstanding strike partnership with Dwight Yorke that saw the pair score 98 goals between them at the peak of the relationship between 1998 and 2000.
Now 45 years of age, Cole retired from playing in 2008. He later returned to United to work towards his coaching qualifications in 2010 and was soon appointed in an ambassadorial role to represent the club at events all over the world.
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